GNAS Antikörper (C-Term)

Produktnummer ABIN952563

Produktdetails anti-GNAS Antikörper

Target: GNAS (GNAS Complex Locus (GNAS))

Bindungsspezifität: AA 286-315, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GNAS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of Human GNAS

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GNAS

Target: GNAS (GNAS Complex Locus (GNAS))

Andere Bezeichnung: GNAS (GNAS Produkte)

Synonyme: AHO antikoerper, C20orf45 antikoerper, GNAS1 antikoerper, GPSA antikoerper, GSA antikoerper, GSP antikoerper, NESP antikoerper, PHP1A antikoerper, PHP1B antikoerper, PHP1C antikoerper, POH antikoerper, GNAS antikoerper, PORGSA1 antikoerper, G-alpha-S antikoerper, 5530400H20Rik antikoerper, A930027G11Rik antikoerper, C130027O20Rik antikoerper, Galphas antikoerper, Gnas1 antikoerper, Gnasxl antikoerper, Gsa antikoerper, Nesp antikoerper, Nespl antikoerper, Oed-Sml antikoerper, Oedsml antikoerper, P1 antikoerper, P2 antikoerper, P3 antikoerper, G-alpha-s antikoerper, gnas-a antikoerper, Gnpas antikoerper, Nesp55 antikoerper, gnal antikoerper, Gnas antikoerper, GNAS complex locus antikoerper, guanine nucleotide-binding protein G(s) subunit alpha antikoerper, GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus antikoerper, GNAS complex locus S homeolog antikoerper, neuroendocrine secretory protein 55-like antikoerper, GNAS antikoerper, LOC694289 antikoerper, LOC469986 antikoerper, Gnas antikoerper, gnas.S antikoerper, gnas antikoerper, LOC100346323 antikoerper, LOC100442753 antikoerper, LOC100732436 antikoerper

Hintergrund: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The Gs protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Alternative splicing of downstream exons of the GNAS gene is observed, which results in different forms of the stimulatory G protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors.

Molekulargewicht: 44,250 Da

Gen-ID: 9606

Pathways: Thyroid Hormone Synthesis, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Embryonic Body Morphogenesis