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IL12B Antikörper (C-Term)

IL12B Reaktivität: Human WB, FACS, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN952920
  • Target Alle IL12B Antikörper anzeigen
    IL12B (Interleukin 12 beta (IL12B))
    Bindungsspezifität
    • 15
    • 11
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 271-298, C-Term
    Reaktivität
    • 68
    • 41
    • 11
    • 9
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 84
    • 20
    • 3
    • 2
    Kaninchen
    Klonalität
    • 87
    • 22
    Polyklonal
    Konjugat
    • 59
    • 10
    • 9
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IL12B Antikörper ist unkonjugiert
    Applikation
    • 86
    • 58
    • 35
    • 16
    • 13
    • 13
    • 13
    • 9
    • 7
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects human Interleukin-12 beta/IL12Bat C-term.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Purified through a protein A column; followed by peptide affinity purification.
    Immunogen
    Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 271-298aa) of human Interleukin-12 beta/IL12B.
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product IL12B Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    IL12B (Interleukin 12 beta (IL12B))
    Andere Bezeichnung
    Interleukin-12 beta / IL12B (IL12B Produkte)
    Synonyme
    CLMF antikoerper, CLMF2 antikoerper, IL-12B antikoerper, NKSF antikoerper, NKSF2 antikoerper, p40 antikoerper, Il-12b antikoerper, Il12p40 antikoerper, Il-12p40 antikoerper, Il12 antikoerper, IL-12p40 antikoerper, IL-12 antikoerper, IL-12 p40 antikoerper, il12b antikoerper, il12p40.b antikoerper, zgc:152789 antikoerper, IL-12.p40 antikoerper, IL12p40 antikoerper, IL12B antikoerper, CLMF p40 antikoerper, interleukin 12B antikoerper, interleukin 12b antikoerper, interleukin 12Ba antikoerper, IL12B antikoerper, Il12b antikoerper, il12ba antikoerper
    Hintergrund
    IL12B is a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2
    Gen-ID
    3593
    NCBI Accession
    NP_002178
    Pathways
    JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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