GSAP Antikörper (C-Term)
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- Target Alle GSAP (PION) Antikörper anzeigen
- GSAP (PION) (Pigeon Homolog (PION))
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Bindungsspezifität
- AA 536-565, C-Term
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GSAP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody recognizes Human PION (C-term).
- Aufreinigung
- Affinity Chromatography on Protein A
- Immunogen
- KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION
- Isotyp
- Ig Fraction
- Top Product
- Discover our top product PION Primärantikörper
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anti-Pigeon Homolog (PION) (AA 616-854) antibody
PION Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Pigeon Homolog (PION) (N-Term) antibodyPION Reaktivität: Human, Ratte, Rind (Kuh), Hund, Pferd, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
anti-Pigeon Homolog (PION) (C-Term) antibodyPION Reaktivität: Human, Ratte, Maus WB, EIA Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.25 mg/mL
- Buffer
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- GSAP (PION) (Pigeon Homolog (PION))
- Andere Bezeichnung
- PION / GSAP (PION Produkte)
- Synonyme
- PION antikoerper, A530088I07Rik antikoerper, Pion antikoerper, gamma-secretase activating protein antikoerper, GSAP antikoerper, Gsap antikoerper
- Hintergrund
- Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog
- Molekulargewicht
- 97802 Da
- Gen-ID
- 54103
- NCBI Accession
- NP_059135
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