STK38 Antikörper (AA 365-466)

Produktnummer ABIN954986

Produktdetails anti-STK38 Antikörper

Target: STK38 (serine/threonine Kinase 38 (STK38))

Bindungsspezifität: AA 365-466

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STK38 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: Recognizes STK38

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Protein A Chromatography

Immunogen: STK38 (AAH12085, 365 a.a. ~ 466 a.a) partial recombinant protein with GST tag.

Klon: 6F1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu STK38

Target: STK38 (serine/threonine Kinase 38 (STK38))

Andere Bezeichnung: STK38 (STK38 Produkte)

Hintergrund: STK38 contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.Synonyms: NDR1, Nuclear Dbf2-related kinase 1, Serine/threonine-protein kinase 38

Gen-ID: 11329

NCBI Accession: NP_009202

UniProt: Q15208