TERT Antikörper (Internal Region)

Produktnummer ABIN955153

Produktdetails anti-TERT Antikörper

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Bindungsspezifität: AA 597-611, Internal Region

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser TERT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: C-QLRELSEAEV RQHRE

Spezifität: This antibody recognizes TERT (597-611). It is expected to recognize both reported isoforms (NP_937983.2, (NP_001180305.1).

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_937983.2, NP_001180305.1. Genename: TERT

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris buffered saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Andere Bezeichnung: TERT (TERT Produkte)

Hintergrund: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.Synonyms: EST2, HEST2, TCS1, TRT, Telomerase catalytic subunit, Telomerase reverse transcriptase, Telomerase-associated protein 2

Gen-ID: 7015

NCBI Accession: NP_001180305

Pathways: Telomere Maintenance