CASZ1 Antikörper (Internal Region)

Produktnummer ABIN964598

Produktdetails anti-CASZ1 Antikörper

Target: CASZ1 (Castor Zinc Finger 1 (CASZ1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Schimpanse, Drosophila melanogaster, Makake

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASZ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: This affinity purified antibody is directed against human CASZ1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with CASZ1 proteins from human, mouse, Drosophila, chimpanzee, and macaque based on a 100% homology. Partial reactivity is expected with horse and dog CASZ1 based on a 92% homology with the immunizing sequence. Cross-reactivity with CASZ1 from other sources has not been determined.

Kreuzreaktivität: Maus, Fruchtfliege (Drosophila melanogaster), Schimpanse, Makake

Produktmerkmale: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. The human castor zinc finger 1 gene (CASZ1) regulates the production of the castor transcription factor, having increased expression when cells of neural and mesenchymal origin are induced to differentiation. CASZ1 is expressed in a number of human tumors and it localizes to a genomic region frequently lost in tumors of neuroectodermal origin. The CASZ1 gene generates 2 mRNA isoforms hCASZ5 and hCASZ11 that could encode proteins containing 5 or 11 zinc finger motifs, respectively. The proteins may be especially labile. Expect a band at 125 kDa for hCASZ5 and 190 kDa for hCASZ11 in fresh lysates.

Aufreinigung: affinity purified

Sterilität: Sterile filtered

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of Human Casz1 protein.
Immunogen Type: Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This antibody has been tested for use in ELISA and western blotting. This antiserum detects endogenous CASZ1 proteins, both the hCASZ5 and hCASZ11 isoforms. Expect a band approximately 125 kDa for hCASZ5 and 190 kDa for hCASZ11 in size corresponding CASZ1 by western blotting in the appropriate cell lysate or extract. Specific conditions for reactivity should be optimized by the end user.

Kommentare:

Gene Name: CASZ1

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.09 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store vial at 4 ° C prior to restoration. For extended storage aliquot contents and freeze at -24 ° C or below. This product is stable for several weeks at 4 ° C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Haltbarkeit: 12 months

Referenzen für anti-CASZ1 Antikörper (ABIN964598)

Lunde, Okaty, Dymecki, Glover: "Molecular Profiling Defines Evolutionarily Conserved Transcription Factor Signatures of Major Vestibulospinal Neuron Groups." in: eNeuro, Vol. 6, Issue 1, (2019) (PubMed).

Zhang, Bonasio, Strino, Kluger, Holloway, Modzelewski, Cohen, Reinberg: "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors." in: Genes & development, Vol. 27, Issue 7, pp. 749-66, (2013) (PubMed).

Details zu CASZ1

Target: CASZ1 (Castor Zinc Finger 1 (CASZ1))

Andere Bezeichnung: CASZ1 (CASZ1 Produkte)

Synonyme: sb:eu580 antikoerper, wu:fk85f10 antikoerper, csta antikoerper, castor antikoerper, CAS11 antikoerper, CST antikoerper, SRG antikoerper, ZNF693 antikoerper, dJ734G22.1 antikoerper, 2410019P08Rik antikoerper, AV096627 antikoerper, BC040081 antikoerper, Cst antikoerper, D4Ertd432e antikoerper, RGD1563533 antikoerper, castor zinc finger 1 antikoerper, castor zinc finger 1 L homeolog antikoerper, CASZ1 antikoerper, casz1 antikoerper, casz1.L antikoerper, Casz1 antikoerper

Hintergrund: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. The human castor zinc finger 1 gene (CASZ1) regulates the production of the castor transcription factor, having increased expression when cells of neural and mesenchymal origin are induced to differentiation. CASZ1 is expressed in a number of human tumors and it localizes to a genomic region frequently lost in tumors of neuroectodermal origin. The CASZ1 gene generates 2 mRNA isoforms hCASZ5 and hCASZ11 that could encode proteins containing 5 or 11 zinc finger motifs, respectively. The proteins may be especially labile. Expect a band at 125 kDa for hCASZ5 and 190 kDa for hCASZ11 in fresh lysates.
Synonyms: CASZ1, Zinc finger protein castor homolog 1, Castor-related protein, Zinc finger protein 693

Gen-ID: 54897, 145207289

UniProt: Q86V15