ESRP1 Antikörper
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- Target Alle ESRP1 Antikörper anzeigen
- ESRP1 (Epithelial Splicing Regulatory Protein 1 (ESRP1))
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Reaktivität
- Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser ESRP1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Hersteller Produkt- Nr.
- 210-301-b89
- Hersteller
- Rockland
- Verwendungszweck
- Esrp-1 Antibody
- Kreuzreaktivität (Details)
- This antibody reacts with mouse Esrp-1 protein.
- Produktmerkmale
- Synonyms: mouse anti-Esrp-1 antibody, mouse anti-Esrp1 antibody, Rbm35a, Epithelial splicing regulatory protein 1, RNA-binding protein 35A, RNA-binding motif protein 35A
- Aufreinigung
- This product is an IgG fraction antibody purified by Protein-A chromatography followed by extensive dialysis against the buffer stated above.
- Sterilität
- Sterile filtered
- Immunogen
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Immunogen: Anti-Esrp-1 was produced by repeated immunizations of full length recombinant mouse Esrp-1 fusion protein.
Immunogen Type: Recombinant Protein
- Klon
- 27H12-F3-H5
- Isotyp
- IgG2b
- Top Product
- Discover our top product ESRP1 Primärantikörper
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- Applikationshinweise
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Application Note: This protein-A purified antibody has been tested for use western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 75.5 kDa in size corresponding to Esrp-1 by western blotting in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1000
ELISA Dilution: 1:750,000
Other: User Optimized
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.0 mg/mL
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide - Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- Haltbarkeit
- 12 months
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Pressure-overload cardiac hypertrophy is associated with distinct alternative splicing due to altered expression of splicing factors." in: Molecules and cells, Vol. 37, Issue 1, pp. 81-7, (2014) (PubMed).
: "An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition." in: The EMBO journal, Vol. 29, Issue 19, pp. 3286-300, (2010) (PubMed).
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Pressure-overload cardiac hypertrophy is associated with distinct alternative splicing due to altered expression of splicing factors." in: Molecules and cells, Vol. 37, Issue 1, pp. 81-7, (2014) (PubMed).
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- Target
- ESRP1 (Epithelial Splicing Regulatory Protein 1 (ESRP1))
- Andere Bezeichnung
- Esrp1 (ESRP1 Produkte)
- Hintergrund
- Background: Epithelial splicing regulatory protein 1 (Esrp-1) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). EsrpP-1 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
- Gen-ID
- 207920
- NCBI Accession
- NP_918944
- UniProt
- Q3US41
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