UBASH3B Antikörper (C-Term)
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- Target Alle UBASH3B (STS1) Antikörper anzeigen
- UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser UBASH3B Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Fluorescence Microscopy (FM)
- Hersteller Produkt- Nr.
- 600-401-870
- Hersteller
- Rockland
- Verwendungszweck
- Sts-1 Antibody
- Kreuzreaktivität (Details)
- This affinity purified antibody is directed against mouse Sts-1 protein.
- Produktmerkmale
- Synonyms: rabbit anti-Sts-1 antibody, Sts1, Sts 1, Ubiquitin-associated and SH3 domain-containing protein B, Cbl interacting protein p70 antibody, Suppressor of T-cell receptor signaling 1, T-cell ubiquitin ligand 2, TULA-2, Tyrosine-protein phosphatase STS1/TULA2, Ubash3B
- Aufreinigung
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
- Sterilität
- Sterile filtered
- Immunogen
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of mouse Sts-1.
Immunogen Type: Conjugated Peptide
- Isotyp
- IgG
- Top Product
- Discover our top product STS1 Primärantikörper
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- Applikationshinweise
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Immunohistochemistry Dilution: 4 μg/mL
Application Note: This affinity purified antibody has been tested for use in ELISA, IHC, and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band
Western Blot Dilution: 1:500 - 1:3,000
ELISA Dilution: 1:2,000 - 1:10,000
IF Microscopy Dilution: User Optimized
Other: User Optimized
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.63 mg/mL
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide - Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- Haltbarkeit
- 12 months
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Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." in: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).
: "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7491-500, (2002) (PubMed).
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Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." in: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).
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- Target
- UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))
- Andere Bezeichnung
- UBASH3B (STS1 Produkte)
- Hintergrund
- Background: Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.
- Gen-ID
- 84959, 24497612
- UniProt
- Q8TF42
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