Purified by antigen-specific affinity chromatography.
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ANKH(Progressive ankylosis protein homolog)
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Williams: "Familial calcium pyrophosphate dihydrate deposition disease and the ANKH gene." in: Current opinion in rheumatology, Vol. 15, Issue 3, pp. 326-31, (2003) (PubMed).
Nelson, Clegg, Arnold, Ferguson, Bonham, White, Hood, Lin: "The program of androgen-responsive genes in neoplastic prostate epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 18, pp. 11890-5, (2002) (PubMed).
Williams, Zhang, Timms, Bonavita, Caeiro, Broxholme, Cuthbertson, Jones, Marchegiani, Reginato, Russell, Wordsworth, Carr, Brown: "Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is caused by mutation in the transmembrane protein ANKH." in: American journal of human genetics, Vol. 71, Issue 4, pp. 985-91, (2002) (PubMed).
The ANKH (progressive ankylosis protein homolog) is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. The ANKHOR and ANKH-TR are novel genetic markers that are significantly associated with ankylosing spondylitis. Mutation at the mouse `progressive ankylosis' (ank) locus causes a generalized, progressive form of arthritis accompanied by mineral deposition, formation of bony outgrowths, and joint destruction. The human homolog is virtually identical to the mouse protein and ANKH-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.