AXL
Reaktivität: Human
WB, ELISA, ICC
Wirt: Maus
Monoclonal
7-00E-10
unconjugated
Applikationshinweise
Western Bloting: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Green, Ikram, Vyas, Patel, Proby, Ghali, Leigh, OToole, Storey: "Overexpression of the Axl tyrosine kinase receptor in cutaneous SCC-derived cell lines and tumours." in: British journal of cancer, Vol. 94, Issue 10, pp. 1446-51, (2006) (PubMed).
Vajkoczy, Knyazev, Kunkel, Capelle, Behrndt, von Tengg-Kobligk, Kiessling, Eichelsbacher, Essig, Read, Erber, Ullrich: "Dominant-negative inhibition of the Axl receptor tyrosine kinase suppresses brain tumor cell growth and invasion and prolongs survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 15, pp. 5799-804, (2006) (PubMed).
JTK11 antikoerper, UFO antikoerper, AI323647 antikoerper, Ark antikoerper, Tyro7 antikoerper, Ufo antikoerper, AXL receptor tyrosine kinase antikoerper, Axl receptor tyrosine kinase antikoerper, AXL antikoerper, Axl antikoerper
Hintergrund
AXL receptor tyrosine kinase, also known as UFO, JTK11. Entrez Protein NP_001690. It is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. Synonyms: UFO, JTK11