ChT Antikörper (C-Term)

Produktnummer ABIN965895

Produktdetails anti-ChT Antikörper

Target: ChT (High Affinity Choline Transporter (ChT))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ChT Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human choline transporter

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-ChT Antikörper (ABIN965895)

Apparsundaram, Ferguson, George, Blakely: "Molecular cloning of a human, hemicholinium-3-sensitive choline transporter." in: Biochemical and biophysical research communications, Vol. 276, Issue 3, pp. 862-7, (2000) (PubMed).

Details zu ChT

Target: ChT (High Affinity Choline Transporter (ChT))

Andere Bezeichnung: CHT1 (ChT Produkte)

Hintergrund: The choline transporter is a hemicholinium-3-sensitive phosphorylated transmembrane protein, the protein regulates high-affinity choline uptake, and plays the roles in disease states. CHT1(High-affinity choline transporter 1) imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. CHT1 is sodium ionand chloride ion-dependent. CHT1 is expressed in putamen, spinal cord and medulla and is specific for cholinergic neurons. CHT1 is specifically inhibited by nanomolar concentrations of hemicholinium 3. CHT1 belongs to the sodium: solute symporter (SSF) (TC 2.A.21) family.