EDEM1 Antikörper (C-Term)
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- Target Alle EDEM1 Antikörper anzeigen
- EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser EDEM1 Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC)
- Aufreinigung
- Purified by antigen-specific affinity chromatography.
- Immunogen
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human EDEM1(ER degradation-enhancing alpha-mannosidase-like 1)
- Top Product
- Discover our top product EDEM1 Primärantikörper
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- Applikationshinweise
- ELISA, Western blotting: 1µg/ml for 2hrs.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- This antibody is stored in PBS, 50% glycerol
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
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Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle." in: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1397-400, (2003) (PubMed).
: "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 3, Issue 5, pp. 321-9, 341-54, (1997) (PubMed).
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Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle." in: Science (New York, N.Y.), Vol. 299, Issue 5611, pp. 1397-400, (2003) (PubMed).
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- Target
- EDEM1 (ER Degradation Enhancer, Mannosidase alpha-Like 1 (EDEM1))
- Andere Bezeichnung
- EDEM1 (EDEM1 Produkte)
- Hintergrund
- EDEM1(ER degradation-enhancing alpha-mannosidase-like 1) extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. It lacks mannosidase activity. EDEM1 is located in endoplasmic reticulum membrane and is a single-pass type II membrane protein. EDEM1 belongs to the glycosyl hydrolase 47 family.
- Pathways
- ER-Nucleus Signaling
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