FER
Reaktivität: Human
WB, ELISA, IHC, IF
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
Western Bloting: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. Immunofluorescence: 1/200 - 1/1000. ELISA: Propose dilution 1/10000. Not yet tested in other applications. Determining optimal working dilutions by titration test.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Li, Cheng, Ling: "Isolation and characterization of Fe(III)-chelate reductase gene LeFRO1 in tomato." in: Plant molecular biology, Vol. 54, Issue 1, pp. 125-36, (2004) (PubMed).
Girault, Greengard: "The neurobiology of dopamine signaling." in: Archives of neurology, Vol. 61, Issue 5, pp. 641-4, (2004) (PubMed).
Fan, Di Ciano-Oliveira, Weed, Craig, Greer, Rotstein, Kapus: "Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase." in: The Biochemical journal, Vol. 380, Issue Pt 2, pp. 581-91, (2004) (PubMed).
FerT antikoerper, PPP1R74 antikoerper, TYK3 antikoerper, Fer antikoerper, Flk antikoerper, Flk_retired antikoerper, AV082135 antikoerper, C330004K01Rik antikoerper, Fert antikoerper, FER tyrosine kinase antikoerper, fer (fms/fps related) protein kinase antikoerper, FER antikoerper, Fer antikoerper
Hintergrund
FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression. Synonyms: TYK3, FER