HSV ICP4 Antikörper (N-Term)

Produktnummer ABIN966334

Produktdetails anti-HSV ICP4 Antikörper

Target: HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))

Bindungsspezifität: N-Term

Reaktivität: Herpes Simplex Virus (HSV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HSV ICP4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of Human herpesvirus 2 ICP4 (Trans-acting transcriptional protein ICP4)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-HSV ICP4 Antikörper (ABIN966334)

Dolan, Jamieson, Cunningham, Barnett, McGeoch: "The genome sequence of herpes simplex virus type 2." in: Journal of virology, Vol. 72, Issue 3, pp. 2010-21, (1998) (PubMed).

Details zu HSV ICP4

Target: HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))

Abstract: HSV ICP4 Produkte

Substanzklasse: Viral Protein

Hintergrund: ICP4 (Trans-acting transcriptional protein ICP4) is a transcriptional transactivator that binds with high affinity to the sequence 5'-ATCGTC-3'. ICP4 may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. ICP4 negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. ICP4 is a homodimer and interacts with transcriptional regulator ICP27, this interaction is required for proper incorporation of ICP4 into virions. The long stretch of Ser is a major site of phosphorylation. Only the phosphorylated forms are capable of interacting with beta or gamma genes. ICP4 belongs to the herpesviridae ICP4/IE140/IE180 family.
Synonyms: IE175 (Infected cell protein 4, Transcriptional activator IE175, Alpha-4 protein)