L3MBTL1 Antikörper (N-Term)

Produktnummer ABIN966472

Produktdetails anti-L3MBTL1 Antikörper

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser L3MBTL1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human L3MBTL(Lethal(3)malignant brain tumor-like protein )

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-L3MBTL1 Antikörper (ABIN966472)

Boccuni, MacGrogan, Scandura, Nimer: "The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 15412-20, (2003) (PubMed).

Wang, Tereshko, Boccuni, MacGrogan, Nimer, Patel: "Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets." in: Structure (London, England : 1993), Vol. 11, Issue 7, pp. 775-89, (2003) (PubMed).

Koga, Matsui, Hirota, Takebayashi, Okumura, Saya: "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes." in: Oncogene, Vol. 18, Issue 26, pp. 3799-809, (1999) (PubMed).

Details zu L3MBTL1

Target: L3MBTL1 (L(3)mbt-Like 1 (L3MBTL1))

Andere Bezeichnung: L3MBTL (L3MBTL1 Produkte)

Synonyme: C630004G01 antikoerper, L3mbtl antikoerper, mKIAA0681 antikoerper, H-L(3)MBT antikoerper, L3MBTL antikoerper, ZC2HC3 antikoerper, dJ138B7.3 antikoerper, RGD1307316 antikoerper, l(3)mbt-like (Drosophila) antikoerper, L3MBTL1, histone methyl-lysine binding protein antikoerper, l(3)mbt-like 1 (Drosophila) antikoerper, L3mbtl1 antikoerper, L3MBTL1 antikoerper

Hintergrund: L3MBTL(Lethal(3)malignant brain tumor-like protein ) is polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. L3MBTL participates in the ETV6-mediated repression. L3MBTL probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis. L3MBTL interacts with ETV6 and is widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60. In interphase cells, it is scattered throughout the nucleoplasm. In mitotic cells, it strongly associates with condensed chromosomes from the prophase to telophase.
Synonyms: KIAA0681, L3MBT, L3MBTL1

Pathways: Chromatin Binding