Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human MAP4 (microtubule-associated protein 4 isoform 4)
MAP4
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Beschränkungen
Nur für Forschungszwecke einsetzbar
Lagerung
4 °C
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Cucchiarelli, Hiser, Smith, Frankfurter, Spano, Correia, Lobert: "Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas." in: Cell motility and the cytoskeleton, Vol. 65, Issue 8, pp. 675-85, (2008) (PubMed).
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Ookata, Hisanaga, Bulinski, Murofushi, Aizawa, Itoh, Hotani, Okumura, Tachibana, Kishimoto: "Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics." in: The Journal of cell biology, Vol. 128, Issue 5, pp. 849-62, (1995) (PubMed).
Chapin, Lue, Yu, Bulinski: "Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains." in: Biochemistry, Vol. 34, Issue 7, pp. 2289-301, (1995) (PubMed).
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Hintergrund
MAP4 (microtubule-associated protein 4 isoform 4) is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. Synonyms: DKFZp779A1753, MGC8617