MEF2D Antikörper (N-Term)

Produktnummer ABIN966557

Produktdetails anti-MEF2D Antikörper

Target: MEF2D (Myocyte Enhancer Factor 2D (MEF2D))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MEF2D Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human MEF2D (Myocyte-specific enhancer factor 2D)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-MEF2D Antikörper (ABIN966557)

Okamoto, Li, Ju, Scholzke, Mathews, Cui, Salvesen, Bossy-Wetzel, Lipton: "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 6, pp. 3974-9, (2002) (PubMed).

Kato, Zhao, Morikawa, Sugiyama, Chakravortty, Koide, Yoshida, Tapping, Yang, Yokochi, Lee: "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family." in: The Journal of biological chemistry, Vol. 275, Issue 24, pp. 18534-40, (2000) (PubMed).

Zhao, New, Kravchenko, Kato, Gram, di Padova, Olson, Ulevitch, Han: "Regulation of the MEF2 family of transcription factors by p38." in: Molecular and cellular biology, Vol. 19, Issue 1, pp. 21-30, (1999) (PubMed).

Breitbart, Liang, Smoot, Laheru, Mahdavi, Nadal-Ginard: "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage." in: Development (Cambridge, England), Vol. 118, Issue 4, pp. 1095-106, (1994) (PubMed).

Details zu MEF2D

Target: MEF2D (Myocyte Enhancer Factor 2D (MEF2D))

Andere Bezeichnung: MEF2D (MEF2D Produkte)

Synonyme: sl1 antikoerper, sl-1 antikoerper, XMEF2D antikoerper, MGC145245 antikoerper, C80750 antikoerper, myocyte enhancer factor 2D antikoerper, MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) antikoerper, mef2d antikoerper, MEF2D antikoerper, Mef2d antikoerper

Hintergrund: MEF2D (Myocyte-specific enhancer factor 2D) is a transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. MEF2D mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. MEF2D plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. MEF2D plays a critical role in the regulation of neuronal apoptosis (By similarity). MEF2D forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells), the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A. Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phsophorylation on Ser-180 can be enhanced by EGF.