ASPSCR1 Antikörper

Produktnummer ABIN967214

Produktdetails anti-ASPSCR1 Antikörper

Target: ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))

Reaktivität: Maus

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser ASPSCR1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: Ni-NTA purified truncated recombinant TUG expressed in E. Coli strain BL21 (DE3)

Aufreinigung: Antibodies are purified by protein A affinity chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.2%BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-ASPSCR1 Antikörper (ABIN967214)

Bogan, Hendon, McKee, Tsao, Lodish: "Functional cloning of TUG as a regulator of GLUT4 glucose transporter trafficking." in: Nature, Vol. 425, Issue 6959, pp. 727-33, (2003) (PubMed).

Details zu ASPSCR1

Target: ASPSCR1 (Alveolar Soft Part Sarcoma Chromosome Region, Candidate 1 (ASPSCR1))

Andere Bezeichnung: TUG (ASPSCR1 Produkte)

Hintergrund: The TUG protein contains a UBX domain, for GLUT4. In truncated form, TUG acts in a dominantnegative manner to inhibit insulin-stimulated GLUT4 redistribution in Chinese hamster ovary cells and 3T3-L1 adipocytes. Full-length TUG forms a complex specifically with GLUT4. In 3T3-L1 adipocytes, this complex is present in unstimulated cells and is largely disassembled by insulin. Endogenous TUG is localized with the insulin-mobilizable pool of GLUT4 in unstimulated 3T3-L1 adipocytes, and is not mobilized to the plasma membrane by insulin.

Gen-ID: 68938