(3 Referenzen)-
- Target Alle TYK2 Antikörper anzeigen
- TYK2 (Tyrosine Kinase 2 (TYK2))
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Reaktivität
- Human
- Wirt
- Bitte anfragen
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Klonalität
- Monoklonal
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Konjugat
- Dieser TYK2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Spezifität
- Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3)
- Aufreinigung
- Crude ascites.
- Isotyp
- IgG1
- Top Product
- Discover our top product TYK2 Primärantikörper
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anti-Tyrosine Kinase 2 (TYK2) (AA 276-375) antibody
TYK2 Reaktivität: Human WB, ELISA, IF, IHC (p), IP Wirt: Maus Monoclonal 6G12 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 276-375) antibodyTYK2 Reaktivität: Human WB, ELISA, IHC (p) Wirt: Maus Monoclonal 6H1 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 750-850) antibodyTYK2 Reaktivität: Human WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (pTyr1054), (pTyr1055) antibodyTYK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 286-372) antibodyTYK2 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 1-1187) antibodyTYK2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) antibodyTYK2 Reaktivität: Human WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) antibodyTYK2 Reaktivität: Human ELISA Wirt: Maus Monoclonal 8G8B3 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (C-Term) antibodyTYK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 1020-1069) antibodyTYK2 Reaktivität: Human, Maus WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Lagerung
- -20 °C
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: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).
: "TYK2 is a key regulator of the surveillance of B lymphoid tumors." in: The Journal of clinical investigation, Vol. 114, Issue 11, pp. 1650-8, (2004) (PubMed).
: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).
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: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).
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- Target
- TYK2 (Tyrosine Kinase 2 (TYK2))
- Andere Bezeichnung
- Tyk2 (TYK2 Produkte)
- Synonyme
- JTK1 antikoerper, tyrosine kinase 2 antikoerper, TYK2 antikoerper, Tyk2 antikoerper
- Hintergrund
- Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
- Gen-ID
- 7297
- Pathways
- JAK-STAT Signalweg, Hepatitis C
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