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MED23 Antikörper

MED23 Reaktivität: Human WB Wirt: Maus Monoclonal D27-1805 unconjugated
Produktnummer ABIN967286
  • Target Alle MED23 Antikörper anzeigen
    MED23 (Mediator Complex Subunit 23 (MED23))
    Reaktivität
    • 38
    • 11
    • 10
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 42
    • 1
    Maus
    Klonalität
    • 42
    • 1
    Monoklonal
    Konjugat
    • 20
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MED23 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 19
    • 13
    • 13
    • 9
    • 8
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB)
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Sur-2 synthetic peptide
    Klon
    D27-1805
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product MED23 Primärantikörper
  • Applikationshinweise
    Applications include western blot analysis (0.2-5.0 µg/ml). HeLa nuclear extracts are recommended as a positive control.
    Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Blobel: "CREB-binding protein and p300: molecular integrators of hematopoietic transcription." in: Blood, Vol. 95, Issue 3, pp. 745-55, (2000) (PubMed).

    Boyer, Martin, Lees, Ricciardi, Berk: "Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein." in: Nature, Vol. 399, Issue 6733, pp. 276-9, (1999) (PubMed).

    Singh, Han: "sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction." in: Genes & development, Vol. 9, Issue 18, pp. 2251-65, (1995) (PubMed).

  • Target
    MED23 (Mediator Complex Subunit 23 (MED23))
    Andere Bezeichnung
    Sur-2 (MED23 Produkte)
    Hintergrund
    SUR-2 (suppressor of ras) is a gene that was originally discovered in the vulval signaling pathway of the nematode Caenorhabditis elegans. Genetic studies suggest that the product of the SUR-2 gene encodes a protein Sur-2, that acts downstream of the Raf/Map kinase pathway. The human homolog of SUR-2 (hSUR-2) was shown to interact with the E1A zinc finger domain from adenovirus. The adenovirus E1A protein can bind to a number of cellular proteins to alter cell cycle progression. E1A exerts this change in the cell cycle by interacting with the transcriptional machinery of the cell. In vitro studies indicate that Sur-2 interacts with the E1A zinc finger protein and the Srb/Mediator transcriptional multiprotein complex. These studies suggest that Sur-2 may play a role as a bridge between E1A and the Srb/Mediator multiprotein complex. However, the roles of Sur-2 in regulating the transcriptional activity of the Srb/Mediator complex and E1A remain to be fully elucidated. Sur-2 has been reported to migrate in SDS/PAGE at 150 kDa2, but our studies indicate that it migrates at approximately 140 kDa. The antibody recognizes human Sur-2. A synthetic peptide corresponding to the N-terminus region of human Sur-2 (METQLQSIFEEVVKTEVIEC) was used as immunogen.
    Molekulargewicht
    140 kDa
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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