Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ITK Antikörper (AA 1-26)

ITK Reaktivität: Human, Maus WB, IP Wirt: Maus Monoclonal 2F12 unconjugated
Produktnummer ABIN967287
  • Target Alle ITK Antikörper anzeigen
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Bindungsspezifität
    • 14
    • 10
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-26
    Reaktivität
    • 49
    • 19
    • 12
    • 6
    • 3
    Human, Maus
    Wirt
    • 62
    • 4
    • 2
    Maus
    Klonalität
    • 64
    • 4
    Monoklonal
    Konjugat
    • 29
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITK Antikörper ist unkonjugiert
    Applikation
    • 41
    • 36
    • 14
    • 14
    • 11
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunoprecipitation (IP)
    Marke
    BD Pharmingen™
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Fusion protein with aa.1-26 of human/mouse Itk
    Klon
    2F12
    Isotyp
    IgG1
    Top Product
    Discover our top product ITK Primärantikörper
  • Kommentare

    Related Products: ABIN968537

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Liu, Bunnell, Gurniak, Berg: "T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells." in: The Journal of experimental medicine, Vol. 187, Issue 10, pp. 1721-7, (1998) (PubMed).

    Heyeck, Wilcox, Bunnell, Berg: "Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity." in: The Journal of biological chemistry, Vol. 272, Issue 40, pp. 25401-8, (1997) (PubMed).

    Siliciano, Morrow, Desiderio: "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 23, pp. 11194-8, (1993) (PubMed).

  • Target
    ITK (IL2-Inducible T-Cell Kinase (ITK))
    Andere Bezeichnung
    ITK (ITK Produkte)
    Synonyme
    Emt antikoerper, Tcsk antikoerper, Tsk antikoerper, EMT antikoerper, LPFS1 antikoerper, LYK antikoerper, PSCTK2 antikoerper, IL2 inducible T cell kinase antikoerper, IL2 inducible T-cell kinase antikoerper, IL2-inducible T-cell kinase antikoerper, Itk antikoerper, ITK antikoerper
    Hintergrund
    Itk (IL-2 inducible tyrosine kinase) is a member of the TEC family of intracellular tyrosine kinases. Members of this family are characterized by their role in hematopoietic cell signaling. Itk is expressed primarily in T cells and has been shown to play a role in T-cell antigen receptor (TCR) mediated proliferation, interleukin-2 production, and T cell differentiation. Itk, following stimulation of the TCR becomes phosphorylated on tyrosine 511 by the Src kinase Lck resulting in increased in vitro Itk kinase activity. If phenylalanine is substituted for tyrosine at position 511, the in vivo kinase activity of Itk is drastically diminished, indicating that this site plays a key role in regulating Itk function. Itk migrates at ~72 kDa on SDS/PAGE. (SWISSPROT: Q08881)
    Molekulargewicht
    72 kDa
    Pathways
    T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung
Sie sind hier:
Kundenservice