Serotonin Receptor 2B Antikörper (AA 1-58)

Produktnummer ABIN967504

Produktdetails anti-Serotonin Receptor 2B Antikörper

Target: Serotonin Receptor 2B (HTR2B)

Bindungsspezifität: AA 1-58

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Serotonin Receptor 2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Marke: BD Pharmingen™

Kreuzreaktivität: Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human 5HT[2B]R (aa. 1-58) fusion protein

Klon: A72-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-Serotonin Receptor 2B Antikörper (ABIN967504)

Duxon, Flanigan, Reavley, Baxter, Blackburn, Fone: "Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system." in: Neuroscience, Vol. 76, Issue 2, pp. 323-9, (1997) (PubMed).

Saudou, Hen: "5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates." in: Neurochemistry international, Vol. 25, Issue 6, pp. 503-32, (1995) (PubMed).

Pompeiano, Palacios, Mengod: "Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors." in: Brain research. Molecular brain research, Vol. 23, Issue 1-2, pp. 163-78, (1994) (PubMed).

Humphrey, Hartig, Hoyer: "A proposed new nomenclature for 5-HT receptors." in: Trends in pharmacological sciences, Vol. 14, Issue 6, pp. 233-6, (1993) (PubMed).

Foguet, Hoyer, Pardo, Parekh, Kluxen, Kalkman, Stühmer, Lübbert: "Cloning and functional characterization of the rat stomach fundus serotonin receptor." in: The EMBO journal, Vol. 11, Issue 9, pp. 3481-7, (1992) (PubMed).

Details zu Serotonin Receptor 2B

Target: Serotonin Receptor 2B (HTR2B)

Andere Bezeichnung: Serotonin Receptor 5-HT 2BR (HTR2B Produkte)

Synonyme: 5-HT2B antikoerper, 5HT2B antikoerper, 5htr2b antikoerper, HTR2B antikoerper, 5ht2b antikoerper, zgc:194094 antikoerper, zgc:194119 antikoerper, AJ012488 antikoerper, AV377389 antikoerper, 5-HT(2B) antikoerper, 5-hydroxytryptamine receptor 2B antikoerper, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled antikoerper, 5-hydroxytryptamine (serotonin) receptor 2B antikoerper, HTR2B antikoerper, htr2b antikoerper, Htr2b antikoerper

Hintergrund: Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor, plays an important role in regulating diverse biological processes in the central and peripheral nervous systems, the cardiovascular system and the gastrointestinal systems. The different functions of serotonin are thought to be mediated through specific receptors. Physiological, biochemical, and pharmacological studies have defined at least fourteen serotonin receptors. The fourteen receptors are grouped in seven subtypes according to operational, structural, and transductional properties. The 5-HT2 receptors (5 -HT[2A]R, 5-HT[2B]R, an d 5-HT[2C]R) may be considered as prototypes for the study of serotonin receptors . Their functions are mediated by the second messenger inositol polyphosphate in a G-protein coupled pathway. They are expressed in diverse tissues including brain, vascular smooth muscles and platelets. The 5-HT[2A]R-mRNAs have been found in only a few areas of the brain, including the frontal cortex, piriform cortex, ventro-caudal part of CA3, motor cranial nerve nuclei in the brainstem, and the ventral horn of the spinal cord. The 5-HT[2C]R mRNA has been found at high levels in many parts of the brain including retrosplenial piriform and entorhinal cortex, anterior olfactory nucleus, substantia nigra pars compacta, several brainstem nuclei and the whole grey matter of the spinal cord. The 5-HT[2B]R was cloned in stomach fundus, where it is abundantly expressed.

Molekulargewicht: 45-55 kDa

Pathways: JAK-STAT Signalweg, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process