MPL Antikörper (Extracellular Domain)

Produktnummer ABIN967682

Produktdetails anti-MPL Antikörper

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Bindungsspezifität: Extracellular Domain

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MPL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human c-Mpl extracellular domain

Klon: 1-78-1

Isotyp: IgG1 kappa

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-MPL Antikörper (ABIN967682)

Abbott, Huang, Ellison, Chen, Arora, Szilvassy, Wei: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." in: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, (2010) (PubMed).

Deng, Banu, Malloy, Hass, Wang, Cavacini, Eaton, Avraham: "An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis." in: Blood, Vol. 92, Issue 6, pp. 1981-8, (1998) (PubMed).

Gotoh, Ritchie, Takahira, Broxmeyer: "Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells." in: Annals of hematology, Vol. 75, Issue 5-6, pp. 207-13, (1998) (PubMed).

Broudy, Lin, Fox, Taga, Saito, Kaushansky: "Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit." in: Blood, Vol. 88, Issue 6, pp. 2026-32, (1996) (PubMed).

Details zu MPL

Target: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Andere Bezeichnung: CD110 (MPL Produkte)

Synonyme: C-MPL antikoerper, CD110 antikoerper, MPLV antikoerper, THCYT2 antikoerper, TPOR antikoerper, TPO-R antikoerper, c-mpl antikoerper, c-mpl-I antikoerper, c-mpl-II antikoerper, hlb219 antikoerper, MPL antikoerper, mpll antikoerper, tpor antikoerper, tpor.b antikoerper, MPL proto-oncogene, thrombopoietin receptor antikoerper, myeloproliferative leukemia virus oncogene antikoerper, MPL antikoerper, Mpl antikoerper, mpl antikoerper

Hintergrund: The 1.78.1 monoclonal antibody specifically binds to the human Thrombopoietin Receptor (TPO-R) that is also know as the Myeloproliferative leukemia protein (c-Mpl) or CD110. CD110 is a type I transmembrane protein and a member of the hematopoietin receptor family. It is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage and platelets. CD110 serves as a receptor for thrombopoietin. Upon binding of thrombopoietin to CD110, megakaryocyte proliferation and differentiation is induced and stem cells are protected from apoptosis.
Synonyms: C-MPL, MPL, MPLV, TPOR, Thrombopoietin receptor

Molekulargewicht: 65-72 kDa (HEL cells) and 80-90 kDa (Platelets)

Pathways: JAK-STAT Signalweg