CNTNAP1 Antikörper (AA 1-1513)

Produktnummer ABIN967780

Produktdetails anti-CNTNAP1 Antikörper

Target: CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))

Bindungsspezifität: AA 1-1513

Reaktivität: Human, Maus, Ratte, Hund, Huhn, Frosch

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CNTNAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Kreuzreaktivität: Hund, Ratte (Rattus), Maus, Huhn, Frosch

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human p190 aa. 1-1513

Klon: 30-p190

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-CNTNAP1 Antikörper (ABIN967780)

Maddox, Burridge: "RhoA is required for cortical retraction and rigidity during mitotic cell rounding." in: The Journal of cell biology, Vol. 160, Issue 2, pp. 255-65, (2003) (PubMed).

Wolf, Draghi, Liang, Dai, Uhrbom, Eklöf, Westermark, Holland, Resh: "p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3." in: Genes & development, Vol. 17, Issue 4, pp. 476-87, (2003) (PubMed).

Brandt, Gimona, Hillmann, Haller, Mischak: "Protein kinase C induces actin reorganization via a Src- and Rho-dependent pathway." in: The Journal of biological chemistry, Vol. 277, Issue 23, pp. 20903-10, (2002) (PubMed).

Nakahara, Mueller, Nomizu, Yamada, Yeh, Chen: "Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 9-12, (1998) (PubMed).

Settleman, Narasimhan, Foster, Weinberg: "Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus." in: Cell, Vol. 69, Issue 3, pp. 539-49, (1992) (PubMed).

Details zu CNTNAP1

Target: CNTNAP1 (Contactin Associated Protein 1 (CNTNAP1))

Andere Bezeichnung: p190 (CNTNAP1 Produkte)

Synonyme: CNTNAP1 antikoerper, CASPR antikoerper, CNTNAP antikoerper, NRXN4 antikoerper, P190 antikoerper, Caspr antikoerper, AI841080 antikoerper, NCP1 antikoerper, Nrxn4 antikoerper, p190 antikoerper, shm antikoerper, contactin associated protein 1 antikoerper, contactin associated protein-like 1 antikoerper, CNTNAP1 antikoerper, cntnap1 antikoerper, Cntnap1 antikoerper

Hintergrund: GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21[ ras]. Ras-GAP (120kDa) is perhaps the best characterized GAP. p190 is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190 are targets of oncoproteins and growth factor receptors. Recombinant p190 enhances GTPase activity of the rho family of GTPases. The complete sequence of p190 exhibits three major regions: an N-terminal region with homology to all GTPases, a middle region homologous to transcriptional repressors, and a C-terminal region the is similar to n-chimerin and other small GTPases.

Molekulargewicht: 190 kDa

Pathways: Cell-Cell Junction Organization