STXBP1 Antikörper (AA 18-1)

Produktnummer ABIN967911

Produktdetails anti-STXBP1 Antikörper

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Bindungsspezifität: AA 18-1

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STXBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Maus, Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat Munc-18-1 aa. 381-567

Klon: 31-Munc

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-STXBP1 Antikörper (ABIN967911)

Curtis, Doneske, Liu, Thaller, McNew, Janz: "Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina." in: The Journal of comparative neurology, Vol. 510, Issue 5, pp. 550-9, (2008) (PubMed).

Torii, Zhao, Yi, Takeuchi, Izumi: "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a." in: Molecular and cellular biology, Vol. 22, Issue 15, pp. 5518-26, (2002) (PubMed).

Fisher, Pevsner, Burgoyne: "Control of fusion pore dynamics during exocytosis by Munc18." in: Science (New York, N.Y.), Vol. 291, Issue 5505, pp. 875-8, (2001) (PubMed).

Zhang, Efanov, Yang, Fried, Kolare, Brown, Zaitsev, Berggren, Meister: "Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta -cell." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41521-7, (2001) (PubMed).

Shuang, Zhang, Fletcher, Groblewski, Pevsner, Stuenkel: "Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings." in: The Journal of biological chemistry, Vol. 273, Issue 9, pp. 4957-66, (1998) (PubMed).

Hata, Slaughter, Südhof: "Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin." in: Nature, Vol. 366, Issue 6453, pp. 347-51, (1993) (PubMed).

Details zu STXBP1

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Andere Bezeichnung: Munc-18 (STXBP1 Produkte)

Synonyme: MUNC18-1 antikoerper, NSEC1 antikoerper, P67 antikoerper, RBSEC1 antikoerper, UNC18 antikoerper, AI317162 antikoerper, AI326233 antikoerper, MMS10-G antikoerper, Ms10g antikoerper, Munc-18a antikoerper, Munc18-1 antikoerper, N-sec1 antikoerper, Rb-sec1 antikoerper, Sxtbp1 antikoerper, Unc18-1 antikoerper, Unc18h antikoerper, nsec1 antikoerper, fj43h10 antikoerper, stxbp1 antikoerper, wu:fj36d12 antikoerper, wu:fj43h10 antikoerper, zgc:114171 antikoerper, rop antikoerper, unc18 antikoerper, hunc18 antikoerper, rbsec1 antikoerper, munc18-1 antikoerper, MGC146482 antikoerper, ANC18HA antikoerper, NSEC1A antikoerper, Sec1 antikoerper, n-sec1 antikoerper, nSec1 antikoerper, rbSec1 antikoerper, rbSec1A antikoerper, rbSec1B antikoerper, UNC18A antikoerper, si:rp71-10d23.3 antikoerper, syntaxin binding protein 1 antikoerper, syntaxin binding protein 1a antikoerper, syntaxin binding protein 1 L homeolog antikoerper, syntaxin binding protein 1b antikoerper, STXBP1 antikoerper, Stxbp1 antikoerper, stxbp1a antikoerper, stxbp1 antikoerper, Tb09.160.0780 antikoerper, stxbp1.L antikoerper, stxbp1b antikoerper

Hintergrund: There are two Munc-18 isoforms: Munc-18-1 and Munc-18-2. Munc-18-1 (n-sec1 or rb-sec1, 68 kDa) is a neuronal protein that binds tightly to syntaxin 1 and functions in synaptic vesicle exocytosis. Munc-18-2 exhibits 63% amino acid sequence identity with Munc-18-1. Although Munc-18-2 is expressed in most tissues, Munc-18-1 is primarily expressed in brain. Both forms of Munc-18 bind tightly to syntaxins 1A, 2, and 3, but not to syntaxin 4. Syntaxin 1A is a plasma membrane protein implicated in synaptic vesicle docking. Following calcium entry into the presynaptic nerve terminal, the neurotransmitter-containing synaptic vesicle fuses with the plasma membrane at a region known as the active zone. Thus, by virtue of its interaction with syntaxin 1A, Munc-18-1 is thought to have an essential function in neurotransmitter release.

Molekulargewicht: 68 kDa

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport