Neuronal Pentraxin (AA 137-312) Antikörper

Produktnummer ABIN967924

Produktdetails

Target: Neuronal Pentraxin

Bindungsspezifität: AA 137-312

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Applikation: Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)

Kreuzreaktivität: Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat Neuronal Pentraxin aa. 137-312

Klon: 22-Neuronal Pentraxin

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen

DeGregorio-Rocasolano, Gasull, Trullas: "Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K(+) in cerebellar granule cells." in: The Journal of biological chemistry, Vol. 276, Issue 1, pp. 796-803, (2001) (PubMed).

Schlimgen, Helms, Vogel, Perin: "Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system." in: Neuron, Vol. 14, Issue 3, pp. 519-26, (1995) (PubMed).

Antigendetails

Target: Neuronal Pentraxin

Hintergrund: Neuronal pentraxin (NP) is a potential receptor for the snake venom toxin, taipoxin. The highest levels of NP mRNA are found in the cerebellum and the CA3 region of the hippocampus. More specifically, NP mRNA is expressed at high levels in Purkinje and granule neurons of the cerebellum and CA3 neurons of the hippocampus. Moderate levels are present in neurons of the hilus, dentate gyrus, CA1, cerebral cortex, medial habenula, anterior hypothalamic nuclei, olfactory cortex, and inferior olivary nuclei. NP mRNA is not expressed in glia of white or gray matter. It is thought that NP serves as a receptor for taipoxin and, after binding, NP-taipoxin is taken into presynaptic terminals. Alternatively, the binding of taipoxin by NP may represent a nonspecific mechanism to sequester toxins from synapses.

Molekulargewicht: 47 kDa