Caveolin 3 Antikörper (AA 3-24)

Produktnummer ABIN967959

Dieses Anti-Caveolin 3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Caveolin 3 in WB, IHC, IP und IF. Geeignet für Maus, Ratte und Kaninchen. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für Caveolin 3 Antikörper (AA 3-24) (ABIN967959)

Target: Caveolin 3 (CAV3)

Reaktivität: Maus, Ratte, Kaninchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Caveolin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Klon: 26-Caveolin 3

Produktdetails anti-Caveolin 3 Antikörper

Bindungsspezifität: AA 3-24

Kreuzreaktivität: Maus, Kaninchen

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat Caveolin 3 aa. 3-24

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: This antibody was tested in development by immunohistochemistry using the SDS Antigen Retreival Method.

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-Caveolin 3 Antikörper (ABIN967959)

Lavitrano, Bacci, Forni, Lazzereschi, Di Stefano, Fioretti, Giancotti, Marfé, Pucci, Renzi, Wang, Stoppacciaro, Stassi, Sargiacomo, Sinibaldi, Turchi, Giovannoni, Della Casa, Seren, Rossi: "Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 22, pp. 14230-5, (2002) (PubMed).

Woodman, Park, Cohen, Cheung, Chandra, Shirani, Tang, Jelicks, Kitsis, Christ, Factor, Tanowitz, Lisanti: "Caveolin-3 knock-out mice develop a progressive cardiomyopathy and show hyperactivation of the p42/44 MAPK cascade." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38988-97, (2002) (PubMed).

Zhao, Liu, Stan, Fan, Gu, Dalton, Chu, Peterson, Ross, Chien: "Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 17, pp. 11375-80, (2002) (PubMed).

Rybin, Xu, Lisanti, Steinberg: "Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41447-57, (2001) (PubMed).

Song, Scherer, Tang, Okamoto, Li, Chafel, Chu, Kohtz, Lisanti: "Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins." in: The Journal of biological chemistry, Vol. 271, Issue 25, pp. 15160-5, (1996) (PubMed).

Details zu Caveolin 3

Target: Caveolin 3 (CAV3)

Andere Bezeichnung: Caveolin 3

Hintergrund: Identified as a tyrosine phosphorylated protein in Rous sarcoma virus-transformed chick embryo fibroblasts (CEF), caveolin is now known to be ubiquitously expressed. Caveolin (also known as VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. This transmembrane protein plays a structural role in these specializations. Caveolin is also present at the trans-Golgi network (TGN), and similar quantities are found in apically and basolaterally destined transport vesicles. Caveolin is part of a complex containing glycosylphosphatidylinositol (GPI)-linked molecules and cytoplasmic signaling proteins. Caveolin is a transmembrane adaptor molecule that can simultaneously recognize GPI-linked proteins and interact with downstream cytoplasmic signaling molecules, such as c-yes, Annexin II, and hetero-trimeric G proteins. Caveolin 3 has been identified as a distinct isoform which is expressed only in smooth, skeletal, and cardiac muscle.

Molekulargewicht: 18 kDa

Pathways: Carbohydrate Homeostasis, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity