CK1 epsilon Antikörper (AA 248-414)

Produktnummer ABIN967975

Produktdetails anti-CK1 epsilon Antikörper

Target: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Bindungsspezifität: AA 248-414

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CK1 epsilon Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Maus, Ratte (Rattus), Huhn, Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Casein Kinase Iepsilon aa. 248-414

Klon: 1-Casein Kinase Iepsilon

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968536, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-CK1 epsilon Antikörper (ABIN967975)

Akashi, Tsuchiya, Yoshino, Nishida: "Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells." in: Molecular and cellular biology, Vol. 22, Issue 6, pp. 1693-703, (2002) (PubMed).

Kishida, Hino Si, Michiue, Yamamoto, Kishida, Fukui, Asashima, Kikuchi: "Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon." in: The Journal of biological chemistry, Vol. 276, Issue 35, pp. 33147-55, (2001) (PubMed).

Peters, McKay, McKay, Graff: "Casein kinase I transduces Wnt signals." in: Nature, Vol. 401, Issue 6751, pp. 345-50, (1999) (PubMed).

Fish, Cegielska, Getman, Landes, Virshup: "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family." in: The Journal of biological chemistry, Vol. 270, Issue 25, pp. 14875-83, (1995) (PubMed).

Details zu CK1 epsilon

Target: CK1 epsilon (CSNK1E) (Casein Kinase 1, epsilon (CSNK1E))

Andere Bezeichnung: Casein Kinase Iepsilon (CSNK1E Produkte)

Synonyme: CKIepsilon antikoerper, HCKIE antikoerper, CKIe antikoerper, ck1-epsilon antikoerper, ck1epsilon antikoerper, hckie antikoerper, dco antikoerper, fj38c01 antikoerper, wu:fj38c01 antikoerper, wu:fj62a04 antikoerper, zgc:77310 antikoerper, AI426939 antikoerper, AI551861 antikoerper, AW457082 antikoerper, CK1epsilon antikoerper, KC1epsilon antikoerper, tau antikoerper, ckie antikoerper, CSNK1E antikoerper, Csnk1e antikoerper, CKI-epsilon antikoerper, 0538/13 antikoerper, 0915/10 antikoerper, 1396/02 antikoerper, 1447/01 antikoerper, 1460/09 antikoerper, CG2048 antikoerper, CK1delta/epsilon antikoerper, DBT antikoerper, DBT/CK1epsilon antikoerper, DCO antikoerper, DCO/CKIe antikoerper, Dbt antikoerper, Dco antikoerper, Dco/CK1 antikoerper, Dmel\CG2048 antikoerper, dCKIepsilon antikoerper, dbt antikoerper, dco-1 antikoerper, ddbt antikoerper, l(3)S053813 antikoerper, l(3)S144701 antikoerper, l(3)dco antikoerper, l(3)dco-1 antikoerper, l(3)discs overgrown antikoerper, l(3)discs overgrown-1 antikoerper, l(3)j3B9 antikoerper, l(3)rK215 antikoerper, casein kinase 1 epsilon antikoerper, casein kinase 1, epsilon antikoerper, casein kinase 1 epsilon L homeolog antikoerper, casein kinase I isoform epsilon antikoerper, casein kinase I epsilon antikoerper, casein kinase I antikoerper, LOC400927-CSNK1E readthrough antikoerper, discs overgrown antikoerper, CSNK1E antikoerper, csnk1e antikoerper, Csnk1e antikoerper, csnk1e.L antikoerper, LOC443240 antikoerper, NAEGRDRAFT_82890 antikoerper, LOC100407384 antikoerper, LOC100523244 antikoerper, LOC100607246 antikoerper, LOC100727500 antikoerper, LOC400927-CSNK1E antikoerper, dco antikoerper

Hintergrund: Casein Kinase Iepsilon (CKIepsilon) is a product of a family of proteins involved in the regulation of various cytoplasmic and nuclear processes including DNA replication and repair. CKIepsilon is a 47.3 kDa serine/threonine kinase that plays a role similar to previously described CKI isoforms. It phosphorylates known CKI substrates, including a CKI-specific peptide. In addition, it is inhibited by CKI-7, an inhibitor of other CKI isoforms. CKIepsilon contains a core kinase domain of 285 amino acids which is 53-98% identical to other isoforms and is most similiar in structure to CKIdelta. Since various human and yeast CKI proteins exhibit both sequence and functional similarities, CKIepsilon may be involved in mammalian DNA metabolism.

Molekulargewicht: 47 kDa

Pathways: Hedgehog Signalweg, M Phase