EPH Receptor A4 Antikörper (AA 279-472)

Produktnummer ABIN967994

Produktdetails anti-EPH Receptor A4 Antikörper

Target: EPH Receptor A4 (EPHA4)

Bindungsspezifität: AA 279-472

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EPH Receptor A4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Ratte (Rattus), Human, Hund, Huhn

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse Sek aa. 279-472

Klon: 35-EphA4

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968545

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-EPH Receptor A4 Antikörper (ABIN967994)

Ellis, Kasmi, Ganju, Walls, Panayotou, Reith: "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn." in: Oncogene, Vol. 12, Issue 8, pp. 1727-36, (1996) (PubMed).

Becker, Gilardi-Hebenstreit, Seitanidou, Wilkinson, Charnay: "Characterisation of the Sek-1 receptor tyrosine kinase." in: FEBS letters, Vol. 368, Issue 2, pp. 353-7, (1995) (PubMed).

Gilardi-Hebenstreit, Nieto, Frain, Mattéi, Chestier, Wilkinson, Charnay: "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain." in: Oncogene, Vol. 7, Issue 12, pp. 2499-506, (1993) (PubMed).

Details zu EPH Receptor A4

Target: EPH Receptor A4 (EPHA4)

Andere Bezeichnung: EphA4 (EPHA4 Produkte)

Synonyme: HEK8 antikoerper, SEK antikoerper, TYRO1 antikoerper, RGD1560587 antikoerper, ephe antikoerper, EPHA4 antikoerper, Ci-Eph1 antikoerper, sek antikoerper, hek8 antikoerper, rtk1 antikoerper, tyr01 antikoerper, 2900005C20Rik antikoerper, AI385584 antikoerper, Cek8 antikoerper, Hek8 antikoerper, Sek antikoerper, Sek1 antikoerper, Tyro1 antikoerper, rb antikoerper, XEpha4 antikoerper, sek-1 antikoerper, epha4 antikoerper, pag antikoerper, EphA4 antikoerper, apha3 antikoerper, ek2 antikoerper, epha3 antikoerper, sb:cb246 antikoerper, zek2 antikoerper, zgc:109882 antikoerper, EPH receptor A4 antikoerper, Eph receptor A4 antikoerper, ephrin receptor epsilon antikoerper, EPH receptor A4 S homeolog antikoerper, EPH receptor A4 L homeolog antikoerper, eph receptor A4a antikoerper, EPHA4 antikoerper, Epha4 antikoerper, ephe antikoerper, epha4 antikoerper, epha4.S antikoerper, epha4.L antikoerper, epha4a antikoerper

Hintergrund: EphA4/Sek is a glycosylated protein tyrosine kinase of 986 amino acids and an apparent 110-130kDa molecular weight (molecular weight depends on glycocylation level of protein). EphA4 belongs to the Eph subfamily of receptor tyrosine kinases and like many others, it has an amino-terminal ligand-binding domain exposed to the extracellar matrix. EphA4 is predominantly expressed during development (this is common in the Eph family) and because of its mRNA localization, it has been proposed that it may play a role during segmentation of the hindbrain and mesoderm. Tyrosine 602 is a major autophosphorylation site of EphA4 and appears to be the docking site for the intracellular tyrosine kinase fyn.

Molekulargewicht: 110-130 kDa

Pathways: RTK Signalweg