DLG4 Antikörper (AA 353-504)

Produktnummer ABIN968003

Produktdetails anti-DLG4 Antikörper

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Bindungsspezifität: AA 353-504

Reaktivität: Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DLG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat PSD-95 aa. 353-504

Klon: 16-PSD

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-DLG4 Antikörper (ABIN968003)

Fagiolini, Katagiri, Miyamoto, Mori, Grant, Mishina, Hensch: "Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2854-9, (2003) (PubMed).

Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

Mehta, Wu, Garner, Marshall: "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16092-9, (2001) (PubMed).

Brenman, Chao, Gee, McGee, Craven, Santillano, Wu, Huang, Xia, Peters, Froehner, Bredt: "Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains." in: Cell, Vol. 84, Issue 5, pp. 757-67, (1996) (PubMed).

Cho, Hunt, Kennedy: "The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein." in: Neuron, Vol. 9, Issue 5, pp. 929-42, (1992) (PubMed).

Details zu DLG4

Target: DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))

Andere Bezeichnung: PSD-95 (DLG4 Produkte)

Synonyme: 11 antikoerper, CG1725 antikoerper, CG1730 antikoerper, CPD antikoerper, DLG antikoerper, DLG-A antikoerper, Discs-large antikoerper, Dlg antikoerper, Dlg-A antikoerper, Dlg1 antikoerper, DlgA antikoerper, Dmel\\CG1725 antikoerper, Drodlg antikoerper, PSD95 antikoerper, SAP97 antikoerper, anon-EST:Posey93 antikoerper, anon-WO03040301.258 antikoerper, anon-WO03040301.260 antikoerper, anon-WO03040301.268 antikoerper, d. lg.-1 antikoerper, dlg antikoerper, dlg-1 antikoerper, dlg-A antikoerper, dlgA antikoerper, dlgS97 antikoerper, l(1)10Bf antikoerper, l(1)G0276 antikoerper, l(1)G0342 antikoerper, l(1)G0456 antikoerper, l(1)G19 antikoerper, l(1)L11 antikoerper, l(1)bwn antikoerper, l(1)d.lg-1 antikoerper, l(1)d.lg.-1 antikoerper, l(1)discs large antikoerper, l(1)dlg antikoerper, l(1)dlg-1 antikoerper, l(1)dlg1 antikoerper, l(1)l.pr.-2 antikoerper, l(1)lpr-2 antikoerper, misb antikoerper, dlgh4 antikoerper, psd95 antikoerper, sap90 antikoerper, sap-90 antikoerper, LLGL1 antikoerper, Dlgh4 antikoerper, PSD-95 antikoerper, SAP90 antikoerper, SAP90A antikoerper, Sap90 antikoerper, SAP-90 antikoerper, DLG4 antikoerper, discs large 1 antikoerper, discs, large homolog 4 antikoerper, discs large MAGUK scaffold protein 4 antikoerper, discs, large homolog 4b (Drosophila) antikoerper, discs, large homolog 4 (Drosophila) antikoerper, dlg1 antikoerper, dlg4 antikoerper, DLG4 antikoerper, dlg4b antikoerper, Dlg4 antikoerper

Hintergrund: PostSynaptic Density (PSD) refers to a dense region of submembranous cytoskeleton found most prominently in postsynaptic membranes of the CNS. Possible functions for the PSD include regulation and aggregation of receptors, structural stabilization of the synaptic junction, and transduction of signals from membrane receptors. Some of the proteins associated with the PSD are fodrin, tubulin, calmodulin, CaM Kinase II, PSD-95, and PSD-93. PSD-95 (SAP90) is a protein that interacts with the NMDA receptor NMDAR2B, neuronal NOS (nNOS or bNOS), and other proteins. PSD-95 contains one SH3 domain in its carboxy-terminal domain, as well as three conserved repeat regions called GLGF or PDZ domains. nNOS, which is concentrated in synaptic junctions, also contains a PZD domain. PSD-95 and nNOS interact via their respective PZD domains, which may mediate the binding of nNOS to skeletal muscle syntrophin. This antibody is routinely tested by western blot analysis.
Synonyms: PostSynaptic Density-95, SAP90

Molekulargewicht: 95 kDa

Pathways: Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity