NUP62 Antikörper (AA 24-178)

Produktnummer ABIN968005

Produktdetails anti-NUP62 Antikörper

Target: NUP62 (Nucleoporin 62kDa (NUP62))

Bindungsspezifität: AA 24-178

Reaktivität: Human, Maus, Ratte, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NUP62 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Huhn, Maus, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Nucleoporin aa. 24-178

Klon: 53-Nucleoporin p62

Isotyp: IgG2b

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-NUP62 Antikörper (ABIN968005)

Paroni, Henderson, Schneider, Brancolini: "Caspase-2 can trigger cytochrome C release and apoptosis from the nucleus." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 15147-61, (2002) (PubMed).

Shah, Patel, Fried, Sehgal: "Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45662-9, (2002) (PubMed).

Daigle, Beaudouin, Hartnell, Imreh, Hallberg, Lippincott-Schwartz, Ellenberg: "Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells." in: The Journal of cell biology, Vol. 154, Issue 1, pp. 71-84, (2001) (PubMed).

Iborra, Jackson, Cook: "The path of RNA through nuclear pores: apparent entry from the sides into specialized pores." in: Journal of cell science, Vol. 113 Pt 2, pp. 291-302, (2000) (PubMed).

Carmo-Fonseca, Kern, Hurt: "Human nucleoporin p62 and the essential yeast nuclear pore protein NSP1 show sequence homology and a similar domain organization." in: European journal of cell biology, Vol. 55, Issue 1, pp. 17-30, (1991) (PubMed).

Details zu NUP62

Target: NUP62 (Nucleoporin 62kDa (NUP62))

Andere Bezeichnung: Nucleoporin p62 (NUP62 Produkte)

Synonyme: IBSN antikoerper, SNDI antikoerper, p62 antikoerper, NUP62 antikoerper, AA589433 antikoerper, AI426861 antikoerper, AI790512 antikoerper, AU045898 antikoerper, D7Ertd649e antikoerper, Nupc1 antikoerper, CG6251 antikoerper, Dmel\\CG6251 antikoerper, DDBDRAFT_0167902 antikoerper, DDBDRAFT_0237712 antikoerper, DDB_0167902 antikoerper, DDB_0237712 antikoerper, nup62 antikoerper, Np62 antikoerper, nucleoporin 62 antikoerper, hypothetical protein antikoerper, nucleoporin 62kDa antikoerper, Nucleoporin 62kD antikoerper, predicted protein antikoerper, nuclear pore protein antikoerper, Nup62 nuclear pore complex glycoprotein p62-related protein (IC) antikoerper, Nuclear pore glycoprotein p62 antikoerper, NUP62 antikoerper, PGTG_03077 antikoerper, Nup62 antikoerper, nup62 antikoerper

Hintergrund: The nuclear pore complex (NPC) acts as a gate to mediate active transport of proteins and RNA into and out of the nucleus. Proteins actively transported into the nucleus through the NPC require specific nuclear localization sequences. Many of these nucleoporins contain N-acetylglucosamine (GlcNAc) residues that are O-linked to serine or threonine. p62 is the best characterized member of a group of nucleoporins that line the central region of the NPC. A tightly associated complex is formed by p62 and two other nucleoporins, p54 and p58. p54 binds to a carboxy-terminal coiled-coil domain of p62 and p58 binds to a dimer of p54. The amino-terminal domain of p62 contains a series of XFXFX repeats and is joined to the coiled-coil domain by a threonine-rich linker segment. The major role of p62 is maintenance of the structural integrity of NPCs.

Molekulargewicht: 62 kDa

Pathways: EGFR Signaling Pathway, SARS-CoV-2 Protein Interaktom