HCLS1 Antikörper (AA 17-190)

Produktnummer ABIN968027

Produktdetails anti-HCLS1 Antikörper

Target: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Bindungsspezifität: AA 17-190

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HCLS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human HS1 aa. 17-190

Klon: 9-HS1

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968536, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-HCLS1 Antikörper (ABIN968027)

Fukuda, Kitamura, Taniuchi, Maekawa, Benhamou, Sarthou, Watanabe: "Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 16, pp. 7302-6, (1995) (PubMed).

Takemoto, Furuta, Li, Strong-Sparks, Hashimoto: "LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck." in: The EMBO journal, Vol. 14, Issue 14, pp. 3403-14, (1995) (PubMed).

Yamanashi, Okada, Semba, Yamori, Umemori, Tsunasawa, Toyoshima, Kitamura, Watanabe, Yamamoto: "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3631-5, (1993) (PubMed).

Details zu HCLS1

Target: HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))

Andere Bezeichnung: HS1 (HCLS1 Produkte)

Synonyme: CTTNL antikoerper, HS1 antikoerper, AW213261 antikoerper, HCLS1 antikoerper, hcls1 antikoerper, si:dkey-9a20.6 antikoerper, wu:fk96b08 antikoerper, zgc:154014 antikoerper, hematopoietic cell-specific Lyn substrate 1 antikoerper, hematopoietic cell specific Lyn substrate 1 antikoerper, hematopoietic lineage cell-specific protein-like antikoerper, HCLS1 antikoerper, Hcls1 antikoerper, LOC100223649 antikoerper, hcls1 antikoerper

Hintergrund: HS1 (lck-binding protein 1 (lckBP1)) is a protein of 486 amino acids with homology to cytoplasmic tyrosine kinases. The protein contains an SH3 domain and two proline-rich regions, that may be the binding site for lck. Co- mmunoprecipitation experiments demonstrated a tight association between HS1 and lck. The SH3 domain of lck is necessary for this interaction. In addition, HS1 contains tandem repeat sequence of seven amino acids which is a substrate for the tyrosine kinase src. This sequence is also found in the protein cortactin. Therefore, HS1, like cortactin, may be an important adaptor that is critical for the regulation of cellular tyrosine kinases. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 75 kDa

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Maintenance of Protein Location