PCNA Antikörper (AA 68-230)
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- Target Alle PCNA Antikörper anzeigen
- PCNA (Proliferating Cell Nuclear Antigen (PCNA))
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Bindungsspezifität
- AA 68-230
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Reaktivität
- Human, Maus, Ratte, Hund
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser PCNA Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- Kreuzreaktivität
- Maus, Ratte (Rattus), Hund
- Produktmerkmale
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human PCNA aa. 68-230
- Klon
- 24-PC
- Isotyp
- IgG1
- Top Product
- Discover our top product PCNA Primärantikörper
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- Kommentare
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Related Products: ABIN968537, ABIN967389
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store undiluted at -20° C.
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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival." in: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 11352-61, (2002) (PubMed).
: "Inactivation of the retinoblastoma protein family can bypass the HCF-1 defect in tsBN67 cell proliferation and cytokinesis." in: Molecular and cellular biology, Vol. 22, Issue 19, pp. 6767-78, (2002) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "The identification of a novel T cell activation state controlled by a diabetogenic gene." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 166, Issue 1, pp. 241-8, (2001) (PubMed).
: "Structure of the human gene for the proliferating cell nuclear antigen." in: The Journal of biological chemistry, Vol. 264, Issue 13, pp. 7466-72, (1989) (PubMed).
: "
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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival." in: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 11352-61, (2002) (PubMed).
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- Target
- PCNA (Proliferating Cell Nuclear Antigen (PCNA))
- Andere Bezeichnung
- PCNA (PCNA Produkte)
- Synonyme
- PCNAR antikoerper, Pcna/cyclin antikoerper, pcna antikoerper, AO090003000846 antikoerper, 53/13 antikoerper, CG9193 antikoerper, DmPCNA antikoerper, Dmel\\CG9193 antikoerper, MUS209 antikoerper, Mus209 antikoerper, PCNA antikoerper, PCNA/mus209 antikoerper, Pcna antikoerper, dPCNA antikoerper, l(2)02448 antikoerper, l(2)56F antikoerper, l(2)56Fa antikoerper, l(2)s1534 antikoerper, cb16 antikoerper, fb36g03 antikoerper, wu:fa28e03 antikoerper, wu:fb36g03 antikoerper, pcna-A antikoerper, proliferating cell nuclear antigen antikoerper, DNA polymerase III sliding clamp antikoerper, Proliferating cell nuclear antigen antikoerper, Proliferating cell nuclear antigen-like antikoerper, proliferating cell nuclear antigen L homeolog antikoerper, proliferating cell nuclear antigen 1 antikoerper, PCNA antikoerper, Pcna antikoerper, pcna antikoerper, MMP_RS08810 antikoerper, ANI_1_512014 antikoerper, AOR_1_1500154 antikoerper, MGC53867 antikoerper, pcna.L antikoerper, pcna1 antikoerper, LOC106420145 antikoerper, pcn1 antikoerper
- Hintergrund
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Progression of the mammalian cell cycle is regulated in two different ways: 1) phosphorylation and dephosphorylation of key proteins, 2) synthesis and degradation of regulatory factors. The Proliferating Cell Nuclear Antigen (PCNA) was initially identified as a nuclear antigen in proliferating cells and was subsequently described as a subunit for DNA polymerase delta. Human PCNA is 262 amino acids with an apparent molecular weight of 36 kDa. PCNA protein levels peak during the S-phase of the cell cycle, at which time it forms a complex with the p21 inhibitor. PCNA is almost undetectable in other phases of the cycle. Because of its unique expression, PCNA has been extensively used in studies associating the prognosis of tumor progression and neoplastic proliferation.
Synonyms: Proliferating Cell Nuclear Antigen - Molekulargewicht
- 36 kDa
- Pathways
- Telomere Maintenance, DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Autophagie
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