NINJ1 Antikörper (AA 1-152)

Produktnummer ABIN968172

Produktdetails anti-NINJ1 Antikörper

Target: NINJ1 (Ninjurin 1 (NINJ1))

Bindungsspezifität: AA 1-152

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NINJ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Hund, Ratte (Rattus), Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Ninjurin aa. 1-152

Klon: 50-Ninjurin

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968587, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-NINJ1 Antikörper (ABIN968172)

Chen, Coustan-Smith, Suzuki, Neale, Mihara, Pui, Campana: "Identification of novel markers for monitoring minimal residual disease in acute lymphoblastic leukemia." in: Blood, Vol. 97, Issue 7, pp. 2115-20, (2001) (PubMed).

Araki, Zimonjic, Popescu, Milbrandt: "Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule." in: The Journal of biological chemistry, Vol. 272, Issue 34, pp. 21373-80, (1997) (PubMed).

Araki, Milbrandt: "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth." in: Neuron, Vol. 17, Issue 2, pp. 353-61, (1996) (PubMed).

Details zu NINJ1

Target: NINJ1 (Ninjurin 1 (NINJ1))

Andere Bezeichnung: Ninjurin (NINJ1 Produkte)

Synonyme: nin1 antikoerper, MGC79511 antikoerper, ninjurin antikoerper, NIN1 antikoerper, NINJURIN antikoerper, AU024536 antikoerper, ninjurin 1 antikoerper, ninjurin 1 L homeolog antikoerper, NINJ1 antikoerper, ninj1 antikoerper, ninj1.L antikoerper, Ninj1 antikoerper

Hintergrund: Ninjurin is a protein whose expression is dramatically increased after sciatic nerve transection and crush injuries. The Ninjurin gene encodes for a protein of 152 amino acids with two putative transmembrane domains. Ninjurin was iodinated in vivo and promoted the aggregation of Jurkat cells expressing Ninjurin, indicating a portion of Ninjurin is exposed to the cell surface. The adhesive properties of Ninjurin were energy and temperature dependent, required Ca2+ and Mg2+, and the integrity of the cytoskeleton. Also, the adhesion domain of Ninjurin is located at the extracellular NH2-terminal domain. Although its predicted mass is 16 kDa, Ninjurin migrates as a 18-22 kDa protein in SDS-PAGE, depending on the cell line or tissue. mRNA analysis revealed that Ninjurin is widely expressed with the highest levels in liver, thymus, heart, and the lowest level in brain.

Molekulargewicht: 18-22 kDa