CASK Antikörper (AA 353-486)

Produktnummer ABIN968174

Produktdetails anti-CASK Antikörper

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Bindungsspezifität: AA 353-486

Reaktivität: Human, Maus, Ratte, Hund, Frosch

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CASK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Maus, Human, Hund, Frosch

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat CASK aa. 353-486

Klon: 7-CASK

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-CASK Antikörper (ABIN968174)

Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

Biederer, Sudhof: "CASK and protein 4.1 support F-actin nucleation on neurexins." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 47869-76, (2001) (PubMed).

Borg, Lõpez-Figueroa, de Taddèo-Borg, Kroon, Turner, Watson, Margolis: "Molecular analysis of the X11-mLin-2/CASK complex in brain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 4, pp. 1307-16, (1999) (PubMed).

Irie, Hata, Takeuchi, Ichtchenko, Toyoda, Hirao, Takai, Rosahl, Südhof: "Binding of neuroligins to PSD-95." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1511-5, (1997) (PubMed).

Hata, Butz, Südhof: "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2488-94, (1996) (PubMed).

Details zu CASK

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Andere Bezeichnung: CASK (CASK Produkte)

Synonyme: CAKI antikoerper, CAMGUK antikoerper, CG13412 antikoerper, CG13413 antikoerper, CG6703 antikoerper, CMG antikoerper, CMG/CASK antikoerper, Caki antikoerper, CamGUK antikoerper, CamguK antikoerper, Camguk antikoerper, Cask antikoerper, Cmg antikoerper, DLin-2 antikoerper, Dmel\\CG6703 antikoerper, RE09582p antikoerper, caki antikoerper, camguk antikoerper, cmg antikoerper, dCASK antikoerper, wu:fb70g06 antikoerper, CAGH39 antikoerper, FGS4 antikoerper, LIN2 antikoerper, MICPCH antikoerper, MRXSNA antikoerper, TNRC8 antikoerper, DXPri1 antikoerper, DXRib1 antikoerper, LIN-2 antikoerper, Pals3 antikoerper, mLin-2 antikoerper, CG6703 gene product from transcript CG6703-RF antikoerper, Peripheral plasma membrane protein CASK antikoerper, CAMK/CASK protein kinase antikoerper, peripheral plasma membrane protein CASK antikoerper, calcium/calmodulin-dependent serine protein kinase b antikoerper, calcium/calmodulin-dependent serine protein kinase a antikoerper, calcium/calmodulin dependent serine protein kinase antikoerper, calcium/calmodulin-dependent serine protein kinase (MAGUK family) antikoerper, calcium/calmodulin-dependent serine protein kinase (MAGUK family) S homeolog antikoerper, CASK antikoerper, Bm1_33725 antikoerper, LOAG_17286 antikoerper, Tsp_03763 antikoerper, caskb antikoerper, caska antikoerper, Cask antikoerper, cask.S antikoerper

Hintergrund: CASK is a recently identified cytosolic protein kinase with homology to the Ca2+/CaM-dependent kinases and the synaptic associated proteins SAPs/PSDs. Like the SAPs, CASK contains a PDZ domain, an SH3 region, and a guanylate kinase domain. However, unlike the rest of the PDZ protein family, the amino terminus of CASK has significant homology with the Ca2+/Calmodulin-dependent kinases. Although widely expressed, CASK is highly enriched in the synaptic plasma membrane where it associates with neurexins, the neuronal cell surface proteins. Neurexins are a complex family of surface proteins that act as receptors for a number of venoms and toxins and regulate the clustering of several ion channels at the synapse. In addition, neurexins bind heterotypically to neuroligins, therefore adjoining different cell types. Neuroligins bind intracellularly to PSD95 and related proteins, whereas neurexins bind to CASK through their C-terminal region and at CASK's PDZ domain. The interaction of neurexins and CASK at the outside of the cell may modulate CASK's activity and trigger an intracellular signaling cascade.

Molekulargewicht: 120 kDa

Pathways: Synaptic Vesicle Exocytosis