Plakophilin 2 Antikörper (AA 19-183)

Produktnummer ABIN968178

Produktdetails anti-Plakophilin 2 Antikörper

Target: Plakophilin 2 (PKP2)

Bindungsspezifität: AA 19-183

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Plakophilin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Plakophilin 2a aa. 19-183

Klon: 28-Plakophilin

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968587, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-Plakophilin 2 Antikörper (ABIN968178)

Mertens, Kuhn, Franke: "Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque." in: The Journal of cell biology, Vol. 135, Issue 4, pp. 1009-25, (1997) (PubMed).

Details zu Plakophilin 2

Target: Plakophilin 2 (PKP2)

Andere Bezeichnung: Plakophilin 2 (PKP2 Produkte)

Synonyme: ARVD9 antikoerper, 1200008D14Rik antikoerper, 1200012P04Rik antikoerper, AA516617 antikoerper, Pkp2l antikoerper, plakophilin 2 antikoerper, PKP2 antikoerper, Pkp2 antikoerper

Hintergrund: Plakophilin 2 is a desmosomal plaque protein that belongs to the arm repeat family of proteins. Alternative splicing results in two isoforms: 2a (837 aa) and 2b (881 aa). The 2b isoform contains an insertion of 44 aa in the arm repeat unit 2. Other arm family members are ß-catenin, plakophilin 1, plakoglobin, pp120, and armadillo of Drosophila gene product. They have at least 9 repeats of the arm motif, which consists of approximately 42 aa, and a short carboxyl terminus. Plakophilins are constitutively expressed in desmosome-containing cells. Plakophilin 1 has been found only in desmosomal-containing cells, such as stratified and complex epithelia. Plakophilin 2 has been isolated from both desmosomal as well as non-desmosomal forming cells, including simple and glandular epithelia, and from nonepithelial tissues such as the mycocardium and Purkinje fibers. In addition, Plakophilin 2 is found in the karyoplasm of interphase cells. Plakophilins 2a and 2b are part of desmosomal plaques, although they are located primarily in the karyoplasm of the interphase nucleus. The function of nuclear plakophilin 2 remains to be identified.

Molekulargewicht: 100 kDa

Pathways: Cell-Cell Junction Organization, SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion