UBE2L3 Antikörper (AA 15-133)

Produktnummer ABIN968215

Produktdetails anti-UBE2L3 Antikörper

Target: UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))

Bindungsspezifität: AA 15-133

Reaktivität: Human, Maus, Ratte, Hund, Frosch

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser UBE2L3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Kreuzreaktivität: Maus, Ratte (Rattus), Hund, Frosch

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human UbcH7 aa. 15-133

Klon: 20-UbcH7

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968537, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-UBE2L3 Antikörper (ABIN968215)

Hagglund, Van Sant, Lopez, Roizman: "Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 631-6, (2002) (PubMed).

Shimura, Schlossmacher, Hattori, Frosch, Trockenbacher, Schneider, Mizuno, Kosik, Selkoe: "Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease." in: Science (New York, N.Y.), Vol. 293, Issue 5528, pp. 263-9, (2001) (PubMed).

Details zu UBE2L3

Target: UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))

Andere Bezeichnung: UbcH7 (UBE2L3 Produkte)

Synonyme: E2-F1 antikoerper, L-UBC antikoerper, UBCH7 antikoerper, UbcM4 antikoerper, C79827 antikoerper, Ubce7 antikoerper, ube2l3 antikoerper, wu:fc22h11 antikoerper, zgc:86727 antikoerper, UBE2L3 antikoerper, ube2l3l antikoerper, wu:fb38h03 antikoerper, ubiquitin conjugating enzyme E2 L3 antikoerper, ubiquitin-conjugating enzyme E2L 3 antikoerper, ubiquitin-conjugating enzyme E2L 3a antikoerper, ubiquitin conjugating enzyme E2 L3 S homeolog antikoerper, ubiquitin-conjugating enzyme E2L 3b antikoerper, UBE2L3 antikoerper, Ube2l3 antikoerper, ube2l3a antikoerper, ube2l3.S antikoerper, ube2l3b antikoerper

Hintergrund: Progression of the mammalian cell cycle is regulated mainly by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an epsilon-NH2-Lys in a target protein. Ubiquitination is a hallmark for rapid protein degradation of the target protein in the proteosome-a cytoplasmic complex of proteases. Several human homologs of the yeast ubiquitin-conjugating enzymes (Ubc) have been identified and found involved in critical processes such as cell cycle progression and apoptosis. UbcH7 was characterized as an E6-AP-interacting protein required for the ubiquitination of p53. E6-AP is the ubiquitin ligase used as bait in the search for interacting proteins required for the proper ubiquitination of cellular targets. UbcH7 interacts with the C-terminal region of E6-AP named the hect domain. Therefore, UbcH7 is another protein, like Ubc9, involved in the degradation and regulation of critical proteins in the cell cycle. This antibody is routinely tested by western blot analysis.
Synonyms: Ubiquitin Conjugating Enzyme H7

Molekulargewicht: 17-18 kDa