Utrophin Antikörper (AA 768-874)

Produktnummer ABIN968237

Produktdetails anti-Utrophin Antikörper

Target: Utrophin (UTRN)

Bindungsspezifität: AA 768-874

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Utrophin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse Utrophin aa. 768-874

Klon: 55-Utrophin

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-Utrophin Antikörper (ABIN968237)

Gramolini, Burton, Tinsley, Ferns, Cartaud, Cartaud, Davies, Lunde, Jasmin: "Muscle and neural isoforms of agrin increase utrophin expression in cultured myotubes via a transcriptional regulatory mechanism." in: The Journal of biological chemistry, Vol. 273, Issue 2, pp. 736-43, (1998) (PubMed).

Deconinck, Rafael, Skinner, Brown, Potter, Metzinger, Watt, Dickson, Tinsley, Davies: "Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy." in: Cell, Vol. 90, Issue 4, pp. 717-27, (1997) (PubMed).

Grady, Teng, Nichol, Cunningham, Wilkinson, Sanes: "Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy." in: Cell, Vol. 90, Issue 4, pp. 729-38, (1997) (PubMed).

Guo, Nichol, Merlie: "Cloning and expression of full length mouse utrophin: the differential association of utrophin and dystrophin with AChR clusters." in: FEBS letters, Vol. 398, Issue 2-3, pp. 259-64, (1997) (PubMed).

Tinsley, Blake, Roche, Fairbrother, Riss, Byth, Knight, Kendrick-Jones, Suthers, Love: "Primary structure of dystrophin-related protein." in: Nature, Vol. 360, Issue 6404, pp. 591-3, (1993) (PubMed).

Details zu Utrophin

Target: Utrophin (UTRN)

Andere Bezeichnung: Utrophin (UTRN Produkte)

Synonyme: drp antikoerper, dmdl antikoerper, drp1 antikoerper, DKFZp469A0710 antikoerper, DMDL antikoerper, DRP antikoerper, DRP1 antikoerper, AA589569 antikoerper, Dmdl antikoerper, utrophin L homeolog antikoerper, utrophin antikoerper, utrn.L antikoerper, UTRN antikoerper, LOAG_03796 antikoerper, utrn antikoerper, LOC100551145 antikoerper, Utrn antikoerper

Hintergrund: Utrophin is an autosomal homolog of dystrophin located on chromosome 6q24. Both encode large cytoskeletal proteins that are members of the spectrin superfamily. Spectrin family proteins are located at the cytoplasmic face and link the intracellular cytoskeleton to the extracellular matrix. Utrophin is nearly identical to dystrophin, specifically in the N-terminal actin binding domain and the C-terminus. Dystrophin is expressed primarily in the brain and muscle, while Utrophin is ubiquitously expressed. In skeletal muscle, Utrophin expression varies depending on the the state of differentiation and innervation of muscle fibers. During development, it localizes in the sarcolemma. Following formation of synaptic contacts, Utrophin is found within the postsynaptic membrane domain of the neuromuscular junction. However, its expression is not limited to postsynaptic compartments. Although dystrophin is absent in patients with Duchenne muscular dystrophy (DMD) and mdx (dystrophin deficient) mice, Utrophin is upregulated. The regulation mechanisms underlying Utrophin expression in muscle have yet to be determined.

Molekulargewicht: 400 kDa

Pathways: Skeletal Muscle Fiber Development