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SRP54 Antikörper (AA 262-476)

SRP54 Reaktivität: Human, Maus, Ratte, Hund, Frosch WB, IF Wirt: Maus Monoclonal 30-SRP54 unconjugated
Produktnummer ABIN968262
  • Target Alle SRP54 Antikörper anzeigen
    SRP54 (Signal Recognition Particle 54kDa (SRP54))
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 262-476
    Reaktivität
    • 47
    • 19
    • 18
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte, Hund, Frosch
    Wirt
    • 44
    • 2
    • 1
    Maus
    Klonalität
    • 43
    • 4
    Monoklonal
    Konjugat
    • 23
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SRP54 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 28
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Hund, Ratte (Rattus), Maus, Frosch
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human SRP54 aa. 262-476
    Klon
    30-SRP54
    Isotyp
    IgG1
    Top Product
    Discover our top product SRP54 Primärantikörper
  • Kommentare

    Related Products: ABIN968537, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Rapiejko, Gilmore: "Empty site forms of the SRP54 and SR alpha GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum." in: Cell, Vol. 89, Issue 5, pp. 703-13, (1997) (PubMed).

    Traianedes, Findlay, Martin, Gillespie: "Modulation of the signal recognition particle 54-kDa subunit (SRP54) in rat preosteoblasts by the extracellular matrix." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 20891-4, (1995) (PubMed).

  • Target
    SRP54 (Signal Recognition Particle 54kDa (SRP54))
    Andere Bezeichnung
    SRP54 (SRP54 Produkte)
    Synonyme
    Srp54k antikoerper, zgc:55842 antikoerper, zgc:85713 antikoerper, SRP54 antikoerper, signal recognition particle 54 antikoerper, signal recognition particle protein antikoerper, signal recognition particle subunit Srp54 antikoerper, signal recognition particle antikoerper, family with sequence similarity 177 member A1 antikoerper, signal recognition particle 54kDa S homeolog antikoerper, signal recognition particle 54kDa antikoerper, SRP54 antikoerper, srp54 antikoerper, SSO_RS04840 antikoerper, MA_RS23935 antikoerper, AF_RS03170 antikoerper, PAB_RS02540 antikoerper, MSP_RS07670 antikoerper, RCI_RS04175 antikoerper, TGAM_RS09885 antikoerper, MTBMA_RS08340 antikoerper, FAM177A1 antikoerper, srp54.S antikoerper, Srp54 antikoerper
    Hintergrund
    Ribosomes that exist freely in the cytosol or those attached to the ER are intrinsically the same in their translational properties. ER-bound ribosomes are responsible for the production of secretory proteins and integral ER, Golgi, lysosomal, and plasma membrane spanning proteins. Such proteins contain signal sequences that direct their synthesis to the ER membrane. As the nascent polypeptide emerges from the ribosome, a signal recognition particle (SRP) binds to the signal sequence and serves to couple the ribosome to the protein-translocating machinery in the ER membrane. Although the SRP is a 325 kDa ribonucleoprotein, its 54 kDa subunit (SRP54) mediates interaction with, and targeting of, the nascent protein to the ER. Via its C-terminal M-domain, SRP54 associates with the nascent protein and inhibits its elongation. This complex binds to the SRP receptor on the ER, the ribosome is delivered to the translocation machinery, SRP is released, and elongation resumes. Targeting and insertion are tightly coupled to a GTPase cycle that involves SRP54 and SRP receptor. Although the mechanisms are unclear, release of SRP from the ER-bound complex requires GTP hydrolysis.
    Molekulargewicht
    54 kDa
    Pathways
    SARS-CoV-2 Protein Interaktom
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