STIM1 Antikörper (AA 25-139)

Produktnummer ABIN968271

Produktdetails anti-STIM1 Antikörper

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Bindungsspezifität: AA 25-139

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STIM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus), Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human GOK aa. 25-139

Klon: 44-GOK

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968548, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-STIM1 Antikörper (ABIN968271)

Hu, Lee, Connors, Johnson, Burn, Su, Landes, Feinberg: "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes." in: Genomics, Vol. 46, Issue 1, pp. 9-17, (1998) (PubMed).

Overall, Parker, Scarcella, Smith, Dziadek: "Murine Stim1 maps to distal chromosome 7 and is not imprinted." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 9, Issue 8, pp. 657-9, (1998) (PubMed).

Yamauchi, Takeuchi, Overall, Dziadek, Munro, Schreiber: "Structural characteristics of bullfrog (Rana catesbeiana) transthyretin and its cDNA--comparison of its pattern of expression during metamorphosis with that of lipocalin." in: European journal of biochemistry / FEBS, Vol. 256, Issue 2, pp. 287-96, (1998) (PubMed).

Parker, Begley, Smith, Fox: "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5." in: Genomics, Vol. 37, Issue 2, pp. 253-6, (1997) (PubMed).

Sabbioni, Barbanti-Brodano, Croce, Negrini: "GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development." in: Cancer research, Vol. 57, Issue 20, pp. 4493-7, (1997) (PubMed).

Details zu STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Andere Bezeichnung: GOK (STIM1 Produkte)

Synonyme: stim1 antikoerper, MGC76045 antikoerper, STIM1 antikoerper, si:dkey-24p1.5 antikoerper, MGC154748 antikoerper, si:ch211-112l17.2 antikoerper, Stim1 antikoerper, D11S4896E antikoerper, GOK antikoerper, TAM antikoerper, SIM antikoerper, stromal interaction molecule 1 antikoerper, stromal interaction molecule 1a antikoerper, stromal interaction molecule 1 L homeolog antikoerper, stromal interaction molecule 1b antikoerper, STIM1 antikoerper, stim1 antikoerper, stim1a antikoerper, stim1.L antikoerper, stim1b antikoerper, Stim1 antikoerper

Hintergrund: The human chromosomal region 11p15 has undergone intense analysis because of its association with various malignancies. In particular, the band 11p15.5 contains genes associated with Wilms tumor, Beckwith-Weidemann syndrome, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. One such gene, GOK (Stim 1), was identified near the 5' end of the ribonucleotide reductase subunit 1 gene. Examination of the GOK primary amino acid sequence indicates that it is a typical transmembrane protein with an extracellular N-terminal domain and a cytosolic C-terminal domain. The protein is highly hydrophobic with only a short region of hydrophobicity that likely represents the transmembrane region. The C-terminal portion of GOK shares some small regions of homology with myosin (20% identity). This region of GOK consists of alpha-helices and is thought to adopt a coiled-coil conformation. Although GOK expression has no effect on the growth of certain breast cancer cell lines, it induces death in rhabdomyosarcoma cells. Thus, it is thought to be a recessive tumor suppressor in muscle cells, possibly by functioning as a receptor connected to an apoptotic signaling pathway.
Synonyms: Stim1

Molekulargewicht: 84 kDa

Pathways: T-Zell Rezeptor Signalweg, BCR Signaling