Metabotropic Glutamate Receptor 1 Antikörper (AA 1042-1160)

Produktnummer ABIN968280

Produktdetails anti-Metabotropic Glutamate Receptor 1 Antikörper

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Bindungsspezifität: AA 1042-1160

Reaktivität: Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat mGluR1 aa. 1042-1160

Klon: 20-mGluR1

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-Metabotropic Glutamate Receptor 1 Antikörper (ABIN968280)

Kryl, Yacoubian, Haapasalo, Castren, Lo, Barker: "Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 14, pp. 5823-33, (1999) (PubMed).

Mary, Gomeza, Prézeau, Bockaert, Pin: "A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C." in: The Journal of biological chemistry, Vol. 273, Issue 1, pp. 425-32, (1998) (PubMed).

Gomeza, Joly, Kuhn, Knöpfel, Bockaert, Pin: "The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins." in: The Journal of biological chemistry, Vol. 271, Issue 4, pp. 2199-205, (1996) (PubMed).

Tanabe, Masu, Ishii, Shigemoto, Nakanishi: "A family of metabotropic glutamate receptors." in: Neuron, Vol. 8, Issue 1, pp. 169-79, (1992) (PubMed).

Masu, Tanabe, Tsuchida, Shigemoto, Nakanishi: "Sequence and expression of a metabotropic glutamate receptor." in: Nature, Vol. 349, Issue 6312, pp. 760-5, (1991) (PubMed).

Details zu Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Andere Bezeichnung: mGluR1 (GRM1 Produkte)

Synonyme: fj39d05 antikoerper, wu:fj39d05 antikoerper, si:ch211-51a19.1 antikoerper, Glura antikoerper, mGlutR antikoerper, GB18621 antikoerper, GPRC1A antikoerper, MGLU1 antikoerper, MGLUR1 antikoerper, SCAR13 antikoerper, 4930455H15Rik antikoerper, ENSMUSG00000075319 antikoerper, Gm10828 antikoerper, Gprc1a antikoerper, mGluR1 antikoerper, nmf373 antikoerper, rcw antikoerper, wobl antikoerper, glutamate metabotropic receptor 1 antikoerper, glutamate receptor, metabotropic 1a antikoerper, metabotropic glutamate receptor 1 antikoerper, glutamate receptor, metabotropic 1 antikoerper, GRM1 antikoerper, grm1a antikoerper, mGlutR1 antikoerper, Grm1 antikoerper

Hintergrund: Glutamate is a major excitatory neurotransmitter and functions in multiple roles in the CNS. The functional diversity of glutamate is exemplified by two distinct groups of glutamate receptors: ionotropic and metabotropic. Coupling with G proteins provides the metabotropic glutamate receptors (mGluRs) with the capacity for intracellular signal transduction. Eight metabotropic glutamate receptors (mGluR1-8) and several Ca[2+] sensing receptors belong to a novel G-protein coupled receptor (GPCR) family. The mGluRs possess the seven putative transmembrane domains which are characteristic of GPCR proteins. However, they exhibit no additional sequence homology to any member of other GPCR families. mGluR1 has large hydrophilic sequences in both the N- and C-terminal sides of the seven transmembrane domains. The sizable extracellular N-terminal domain is homologous to bacterial periplasmic binding proteins and serves as the glutamate binding site. mGluR1 activates phospholipase C (PLC), resulting in phosphoinositide turnover and, in turn, Ca2+ mobilization necessary for many signal transduction events.
Synonyms: Metabotropic Glutamate Receptor-1

Molekulargewicht: 133 kDa