SRPK1 Antikörper (AA 312-434)

Produktnummer ABIN968353

Produktdetails anti-SRPK1 Antikörper

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Bindungsspezifität: AA 312-434

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SRPK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Hund, Ratte (Rattus), Maus

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human SRPK1 aa.312-434

Klon: 12-SRPK1

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968535, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-SRPK1 Antikörper (ABIN968353)

Wang, Lin, Dyck, Yeakley, Songyang, Cantley, Fu: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).

Colwill, Feng, Yeakley, Gish, Cáceres, Pawson, Fu: "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors." in: The Journal of biological chemistry, Vol. 271, Issue 40, pp. 24569-75, (1996) (PubMed).

Details zu SRPK1

Target: SRPK1 (SRSF Protein Kinase 1 (SRPK1))

Andere Bezeichnung: SRPK1 (SRPK1 Produkte)

Synonyme: SFRSK1 antikoerper, AU017960 antikoerper, BEST:CK01209 antikoerper, CG11489 antikoerper, CG9085 antikoerper, CK01209 antikoerper, Dmel\\CG11489 antikoerper, SRPK antikoerper, SRPK1 antikoerper, Srpk79D antikoerper, atc antikoerper, srpk1 antikoerper, zgc:63789 antikoerper, wu:fc06h03 antikoerper, zgc:158800 antikoerper, sfrsk1 antikoerper, SRSF protein kinase 1 antikoerper, serine/arginine-rich protein specific kinase 1 antikoerper, Serine-arginine protein kinase at 79D antikoerper, SRSF protein kinase 1a antikoerper, SRSF protein kinase 1b antikoerper, SRSF protein kinase 1 S homeolog antikoerper, SRPK1 antikoerper, Srpk1 antikoerper, Srpk79D antikoerper, srpk1a antikoerper, srpk1b antikoerper, srpk1.S antikoerper

Hintergrund: Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The super family of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate SR domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPL1 is specific for SR domain-containing splicing factors because it recognizes only Arg and phosphorylates only Ser. SRPK1 is expressed predominately in the pancreas, domain-containing splicing factors because it recognizes only Arg and phosphorylates only Ser. SRPK1 is expressed predominately in the pancreas, whereas SRPK2 is highly expressed in brain. SRPKs affect splice-site selection and are thought to affect alternative splicing.

Molekulargewicht: 92 kDa

Pathways: Toll-Like Receptors Cascades