Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

NCOA3 Antikörper (AA 376-389)

NCOA3 Reaktivität: Human, Maus, Ratte WB, IF Wirt: Maus Monoclonal 34-AIB unconjugated
Produktnummer ABIN968368
  • Target Alle NCOA3 Antikörper anzeigen
    NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))
    Bindungsspezifität
    • 15
    • 14
    • 9
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 376-389
    Reaktivität
    • 61
    • 16
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 55
    • 7
    • 1
    • 1
    Maus
    Klonalität
    • 58
    • 6
    Monoklonal
    Konjugat
    • 33
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NCOA3 Antikörper ist unkonjugiert
    Applikation
    • 38
    • 24
    • 13
    • 13
    • 11
    • 9
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human AIB-1 aa. 376-389
    Klon
    34-AIB
    Isotyp
    IgG1
    Top Product
    Discover our top product NCOA3 Primärantikörper
  • Kommentare

    Related Products: ABIN968537, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Louie, Yang, Ma, Xu, Zou, Kung, Chen: "Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2226-30, (2003) (PubMed).

    Lauritsen, List, Reiter, Wellstein, Riegel: "A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells." in: Oncogene, Vol. 21, Issue 47, pp. 7147-55, (2002) (PubMed).

    Reiter, Wellstein, Riegel: "An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 39736-41, (2001) (PubMed).

    Eng, Barsalou, Akutsu, Mercier, Zechel, Mader, White: "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain." in: The Journal of biological chemistry, Vol. 273, Issue 43, pp. 28371-7, (1998) (PubMed).

    Anzick, Kononen, Walker, Azorsa, Tanner, Guan, Sauter, Kallioniemi, Trent, Meltzer: "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 965-8, (1997) (PubMed).

  • Target
    NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))
    Andere Bezeichnung
    AIB-1 (NCOA3 Produkte)
    Synonyme
    NCOA3 antikoerper, ACTR antikoerper, AIB-1 antikoerper, AIB1 antikoerper, CAGH16 antikoerper, CTG26 antikoerper, KAT13B antikoerper, RAC3 antikoerper, SRC-3 antikoerper, SRC3 antikoerper, TNRC14 antikoerper, TNRC16 antikoerper, TRAM-1 antikoerper, bHLHe42 antikoerper, pCIP antikoerper, 2010305B15Rik antikoerper, AW321064 antikoerper, Actr antikoerper, Aib1 antikoerper, Rac3 antikoerper, Src3 antikoerper, Tram-1 antikoerper, Tram1 antikoerper, p/Cip antikoerper, pCip antikoerper, actr antikoerper, aib-1 antikoerper, aib1 antikoerper, cagh16 antikoerper, ctg26 antikoerper, kat13b antikoerper, pcip antikoerper, rac3 antikoerper, src-3 antikoerper, src3 antikoerper, tnrc14 antikoerper, tnrc16 antikoerper, tram-1 antikoerper, xSRC-3 antikoerper, nuclear receptor coactivator 3 antikoerper, nuclear receptor coactivator 3 S homeolog antikoerper, NCOA3 antikoerper, Ncoa3 antikoerper, ncoa3.S antikoerper
    Hintergrund
    Signal transduction via nuclear hormone receptors is important for cell growth and differentiation, development, and homeostasis. Nuclear hormone receptors are ligand-activated transcription factors that modulate target gene expression. These ligand/receptor complexes also interact with transcriptional coactivators which enhance ligand-dependent transcription. Various classes of coactivators have been identified, including SRC-1 and its related proteins, such as TIF-2/GRIP-1, RIP140, AIB-1, and TIF-1alpha and -1beta. AIB-1 (Amplified In Breast cancer-1) is also known as pCIP, RAC3, and TRAM-1. It interacts with estrogen receptor (ER) and is overexpressed in breast cancer biopsies and several breast and ovarian cancer cell lines. Similar to SRC-1 and TIF2, AIB-1 contains a basic helix-loop-helix (bHLH) domain followed by a PAS (Per/Arnt/Sim) region, serine and threonine rich regions, and a charged cluster. In addition, AIB-1 contains three copies of the conserved LXXLL motif which is critical to its interaction with the nuclear receptor. Thus, AIB-1 is a coactivator of nuclear receptors that may participate in the development of steroid-dependent cancers.
    Synonyms: Amplified In Breast cancer-1, pCIP, RAC3, TRAM-1
    Molekulargewicht
    160 kDa
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha
Sie sind hier:
Kundenservice