CSRP2 Antikörper (AA 601-722)

Produktnummer ABIN968372

Produktdetails anti-CSRP2 Antikörper

Target: CSRP2 (Cysteine and Glycine-Rich Protein 2 (CSRP2))

Bindungsspezifität: AA 601-722

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CSRP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Maus, Human, Hund

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat DLP1 aa. 601-722

Klon: 8-DLP1

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389, ABIN968545

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-CSRP2 Antikörper (ABIN968372)

Bossy, Petrilli, Klinglmayr, Chen, Lütz-Meindl, Knott, Masliah, Schwarzenbacher, Bossy-Wetzel: "S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease." in: Journal of Alzheimer's disease : JAD, Vol. 20 Suppl 2, Issue 6, pp. S513-26, (2010) (PubMed).

Estaquier, Arnoult: "Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis." in: Cell death and differentiation, Vol. 14, Issue 6, pp. 1086-94, (2007) (PubMed).

Karbowski, Neutzner, Youle: "The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division." in: The Journal of cell biology, Vol. 178, Issue 1, pp. 71-84, (2007) (PubMed).

Duvezin-Caubet, Jagasia, Wagener, Hofmann, Trifunovic, Hansson, Chomyn, Bauer, Attardi, Larsson, Neupert, Reichert: "Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology." in: The Journal of biological chemistry, Vol. 281, Issue 49, pp. 37972-9, (2006) (PubMed).

Jofuku, Ishihara, Mihara: "Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating protein." in: Biochemical and biophysical research communications, Vol. 333, Issue 2, pp. 650-9, (2005) (PubMed).

Yoon, Pitts, Dahan, McNiven: "A novel dynamin-like protein associates with cytoplasmic vesicles and tubules of the endoplasmic reticulum in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 779-93, (1998) (PubMed).

Details zu CSRP2

Target: CSRP2 (Cysteine and Glycine-Rich Protein 2 (CSRP2))

Andere Bezeichnung: DLP1 (CSRP2 Produkte)

Synonyme: CRP2 antikoerper, LMO5 antikoerper, SmLIM antikoerper, crp2 antikoerper, lmo5 antikoerper, csrp1 antikoerper, smlim antikoerper, AW551867 antikoerper, Crp2 antikoerper, SmLim antikoerper, zgc:77740 antikoerper, BETA-CRP antikoerper, csrp2 antikoerper, MGC81964 antikoerper, CSRP2 antikoerper, cysteine and glycine rich protein 2 antikoerper, cysteine and glycine-rich protein 2 antikoerper, cysteine and glycine rich protein 2 L homeolog antikoerper, cysteine and glycine rich protein 2 S homeolog antikoerper, CSRP2 antikoerper, csrp2 antikoerper, Csrp2 antikoerper, csrp2.L antikoerper, csrp2.S antikoerper

Hintergrund: Dynamins, phosphoproteins with intrinsic GTPase activities, play an important role during early endocytosis. The GTPase activity is stimulated in vitro by microtubules, SH3 domain containing-proteins, and Protein Kinase (PKC)- mediated phosphorylation. Although highly related, dynamins are differentially expressed in an organism. For instance, dynamin I is found only in the nervous system, dynamin II is ubiquitously expressed, and dynamin III is located in lung, testis and brain. Due to four alternative splicing products for each of the dynamins, the dynamin family contains at least 12 different members. The Dynamin Like Protein-1 (DLP1) is a new member of the dynamin family of proteins. DLP1 (also known as DVLP) is widely expressed as two alternatively spliced products, each with different tissue expression patterns. The larger product is about 84 kDa and reportedly found only in the brain, whereas the 79 kDa product is ubiquitously expressed. Unlike dynamins I-III which co-localize with endocytotic vesicles, DLP1 is found aligned with microtubules and with the endoplasmic reticulum, suggesting a secretory function for this novel protein.
Synonyms: Dynamin Like Protein-1, DVLP

Molekulargewicht: 79-84 kDa