G3BP1 Antikörper (AA 210-323)

Produktnummer ABIN968381

Produktdetails anti-G3BP1 Antikörper

Target: G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))

Bindungsspezifität: AA 210-323

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser G3BP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human G3BP aa. 210-323

Klon: 23-G3BP

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968552, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-G3BP1 Antikörper (ABIN968381)

Gallouzi, Parker, Chebli, Maurier, Labourier, Barlat, Capony, Tocque, Tazi: "A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability." in: Molecular and cellular biology, Vol. 18, Issue 7, pp. 3956-65, (1998) (PubMed).

Parker, Maurier, Delumeau, Duchesne, Faucher, Debussche, Dugue, Schweighoffer, Tocque: "A Ras-GTPase-activating protein SH3-domain-binding protein." in: Molecular and cellular biology, Vol. 16, Issue 6, pp. 2561-9, (1996) (PubMed).

Details zu G3BP1

Target: G3BP1 (GTPase Activating Protein (SH3 Domain) Binding Protein 1 (G3BP1))

Andere Bezeichnung: G3BP (G3BP1 Produkte)

Synonyme: G3BP antikoerper, HDH-VIII antikoerper, fj17h05 antikoerper, zgc:56034 antikoerper, wu:fj17h05 antikoerper, g3bp antikoerper, MGC53271 antikoerper, G3BP1 antikoerper, G3bp antikoerper, RGD1310666 antikoerper, AI849976 antikoerper, B430204O07 antikoerper, C87777 antikoerper, mKIAA4115 antikoerper, G3BP stress granule assembly factor 1 antikoerper, GTPase activating protein (SH3 domain) binding protein 1 antikoerper, GTPase activating protein (SH3 domain) binding protein 1 L homeolog antikoerper, Ras-GTPase-activating protein SH3-domain-binding protein antikoerper, G3BP1 antikoerper, g3bp1 antikoerper, g3bp1.L antikoerper, LOC100304885 antikoerper, G3bp1 antikoerper

Hintergrund: The Ras proteins are low molecular weight GTPases that play a critical role in the control of proliferation, differentiation, and cytoskeletal organization. RasGAP acts as a negative regulator of Ras, as well as a downstream target of Ras. It participates in the signal transduction cascade through interactions with other signaling proteins. Via its C-terminal domain, RasGAP interacts with Ras, but the N-terminus interacts with other signaling molecules such as p62 and p190. This function of RasGAP is mediated by the presence of SH2, SH3, and PH domains in the N-terminal region. However, some signaling proteins cannot bind to these domains. In an attempt to identify RasGAP-interacting molecules, a GAP SH3-Binding Protein (G3BP) was identified. This protein exhibits sequence homology to the hnRNP superfamily. It contains RNP1 and RNP2 motifs and is found primarily in the cytosol. G3BP interacts with GAP in proliferating cells and is dependent on the activation state of Ras. In addition, G3BP contains an intrinsic endonuclease activity that cleaves 3'-untranslated region (3'-UTR) mRNA. These data indicate that G3BP may link the Ras pathway to mRNA degradation.

Molekulargewicht: 55-70 kDa

Pathways: SARS-CoV-2 Protein Interaktom