STXBP5 Antikörper (AA 910-1105)

Produktnummer ABIN968460

Produktdetails anti-STXBP5 Antikörper

Target: STXBP5 (Syntaxin Binding Protein 5 (Tomosyn) (STXBP5))

Bindungsspezifität: AA 910-1105

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STXBP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), BioImaging (BI)

Kreuzreaktivität: Maus, Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat Tomosyn aa. 910-1105

Klon: 15-Tomosyn

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-STXBP5 Antikörper (ABIN968460)

Yokoyama, Shirataki, Sakisaka, Takai: "Three splicing variants of tomosyn and identification of their syntaxin-binding region." in: Biochemical and biophysical research communications, Vol. 256, Issue 1, pp. 218-22, (1999) (PubMed).

Fujita, Shirataki, Sakisaka, Asakura, Ohya, Kotani, Yokoyama, Nishioka, Matsuura, Mizoguchi, Scheller, Takai: "Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process." in: Neuron, Vol. 20, Issue 5, pp. 905-15, (1998) (PubMed).

Details zu STXBP5

Target: STXBP5 (Syntaxin Binding Protein 5 (Tomosyn) (STXBP5))

Andere Bezeichnung: Tomosyn (STXBP5 Produkte)

Synonyme: LGL3 antikoerper, LLGL3 antikoerper, Nbla04300 antikoerper, 0710001E20Rik antikoerper, 4930565N16Rik antikoerper, AW742610 antikoerper, mKIAA1006 antikoerper, syntaxin binding protein 5 antikoerper, syntaxin binding protein 5 (tomosyn) antikoerper, STXBP5 antikoerper, Stxbp5 antikoerper

Hintergrund: Neuronal signal transmission and neurotransmitter release from the presynaptic nerve terminal is mediated by the synaptic vesicle cycle. Syntaxin plays a central role during vesicle docking and fusion through interactions with many vesicle components. During docking, vSNAREs (VAMP/synaptobrevin, synaptotagmin) on the synaptic vesicle and tSNAREs (SNAP-25, syntaxin) on the plasma membrane interact to form a 7S complex, which is essential to docking and fusion. Syntaxin associates with munc18/n-sec1 prior to and/or during the formation of the 7S complex. This interaction may inhibit syntaxin binding proteins (VAMP, SNAP-25) that facilitate vesicle docking or fusion. Tomosyn, a syntaxin binding protein, displaces munc18 from syntaxin-1 and forms a novel 10S complex with syntaxin-1, SNAP-25, and synaptogamin. There are two splice variants of tomosyn designated b-tomosyn and s-tomosyn, while the original is referred to as m-tomosyn. Although b-tomosyn is ubiquitously expressed, s-tomosyn and m-tomosyn are expressed primarily in brain. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 130 kDa