IKBKG Antikörper (AA 278-396)
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- Target Alle IKBKG Antikörper anzeigen
- IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
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Bindungsspezifität
- AA 278-396
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Reaktivität
- Human, Ratte, Hund
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser IKBKG Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF)
- Kreuzreaktivität
- Ratte (Rattus), Human, Hund
- Produktmerkmale
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Mouse IKKgamma/NEMO aa. 278-396
- Klon
- 54-IKKgamma-NEMO
- Isotyp
- IgG1
- Top Product
- Discover our top product IKBKG Primärantikörper
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- Kommentare
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Related Products: ABIN968547, ABIN967389
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store undiluted at -20° C.
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Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor." in: Immunity, Vol. 18, Issue 1, pp. 13-26, (2003) (PubMed).
: "IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1." in: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15297-300, (1999) (PubMed).
: "Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17402-5, (1999) (PubMed).
: "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 297-300, (1998) (PubMed).
: "Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation." in: Cell, Vol. 93, Issue 7, pp. 1231-40, (1998) (PubMed).
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Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor." in: Immunity, Vol. 18, Issue 1, pp. 13-26, (2003) (PubMed).
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- Target
- IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
- Andere Bezeichnung
- IKK gamma (IKBKG Produkte)
- Synonyme
- AMCBX1 antikoerper, FIP-3 antikoerper, FIP3 antikoerper, Fip3p antikoerper, IKK-gamma antikoerper, IP antikoerper, IP1 antikoerper, IP2 antikoerper, IPD2 antikoerper, NEMO antikoerper, ZC2HC9 antikoerper, 1110037D23Rik antikoerper, AI848108 antikoerper, AI851264 antikoerper, AW124339 antikoerper, IKK[g] antikoerper, Nemo antikoerper, nemo antikoerper, fj33c07 antikoerper, wu:fj33c07 antikoerper, zgc:113492 antikoerper, MGC97885 antikoerper, IKBKG antikoerper, IKBKG_1 antikoerper, IKBKG_2 antikoerper, CG16910 antikoerper, DmIKK-gamma antikoerper, DmIKKgamma antikoerper, Dmel\\CG16910 antikoerper, Dmikkgamma antikoerper, IKK antikoerper, IKK[[gamma]] antikoerper, IKKg antikoerper, IKKgamma antikoerper, KEY antikoerper, Kenny antikoerper, Key antikoerper, dIKK antikoerper, dIKK-gamma antikoerper, dmIKKgamma antikoerper, inhibitor of nuclear factor kappa B kinase subunit gamma antikoerper, inhibitor of kappaB kinase gamma antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma antikoerper, inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog antikoerper, kenny antikoerper, IKBKG antikoerper, Ikbkg antikoerper, ikbkg antikoerper, ikbkg.L antikoerper, IKBKG_1 antikoerper, key antikoerper
- Hintergrund
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In most cells, NF-kappaB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkappaBalpha, IkappaBbeta, and IkappaBepsilon. Cell stimulation induces the release, activation, and nuclear translocation of NF-kappaB. Release of NF-kappaB results from the phosphorylation and subsequent proteolytic degradation of the IkappaB proteins. Two cytokine-inducible IkappaB kinases (IKKalpha and IKKbeta) phosphorylate and target the IkappaB proteins for degradation by the ubiquitin pathway. These kinases are components of a 700-900 kDa multisubunit complex that also contains NF-kappaB/RelA, IkappaBalpha, MEKK1, NIK, IKAP, and IKKgamma/NEMO (NF-kappaB essential modulator). IKKgamma contains two coiled-coil domains and a leucine zipper which allow it to form dimers and trimers that interact directly with IKKbeta. IKKgamma, essential for IKKalpha/IKKbeta activation of NF-kappaB, is located functionally and physically upstream of these subunits. In addition, IKKgamma enables the HTLV-1 Tax oncoprotein to interact with IKKbeta, resulting in constitutive activation of NF-kappaB and maintenance of cellular transformation. Thus, IKKgamma is an essential element of the IkappaB complex and an adaptor that mediates stable formation of Tax-IKK complexes.
Synonyms: NEMO - Molekulargewicht
- 48 kDa
- Pathways
- NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, M Phase, Production of Molecular Mediator of Immune Response, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine
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