NMT2 Antikörper (AA 10-119)

Produktnummer ABIN968466

Produktdetails anti-NMT2 Antikörper

Target: NMT2 (N-Myristoyltransferase 2 (NMT2))

Bindungsspezifität: AA 10-119

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NMT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human NMT-2 aa. 10-119

Klon: 30-NMT

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-NMT2 Antikörper (ABIN968466)

Giang, Cravatt: "A second mammalian N-myristoyltransferase." in: The Journal of biological chemistry, Vol. 273, Issue 12, pp. 6595-8, (1998) (PubMed).

Details zu NMT2

Target: NMT2 (N-Myristoyltransferase 2 (NMT2))

Andere Bezeichnung: NMT-2 (NMT2 Produkte)

Synonyme: NMT2 antikoerper, A930001K02Rik antikoerper, AI605445 antikoerper, AU044698 antikoerper, hNMT-2 antikoerper, NMT 2 antikoerper, fb40e03 antikoerper, wu:fb40e03 antikoerper, N-myristoyltransferase 2 antikoerper, NMT2 antikoerper, Bm1_22900 antikoerper, LOAG_05681 antikoerper, nmt2 antikoerper, Nmt2 antikoerper

Hintergrund: Myristoylation is an essential cotranslational modification for many mammalian, viral, and fungal signaling proteins. N-terminal myristoylation is a lipid modification that is catalyzed by N-myristoyltransferase (NMT). NMT transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. This modification is important for localization and/or function of many of these proteins. Two human NMTs (NMT-1, NMT-2) have been identified. These proteins share 95% amino acid identity with their mouse homologs. NMT-1 is processed to form four protein isoforms with molecular weights ranging from 49-68 kDa. It is not known if these four isoforms are derived from single or multiple gene(s) and their exact functional roles are yet to be determined. In contrast to NMT-1, NMT-2 is a single 65 kDa protein. It contains 77% sequence identity with NMT-1, indicating that these proteins comprise two distinct families with overlapping, but distinct, substrate preferences. Additionally, NMT enzymatic activity is increased in colorectal tumors. Thus, NMTs are transferases whose function is essential for biological function of a variety of signaling proteins.

Molekulargewicht: 65 kDa

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling