STRAP Antikörper (AA 42-154)

Produktnummer ABIN968485

Produktdetails anti-STRAP Antikörper

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Bindungsspezifität: AA 42-154

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STRAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus), Human

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse STRAP aa. 42-154

Klon: 22-STRAP

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-STRAP Antikörper (ABIN968485)

Datta, Chytil, Gorska, Moses: "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling." in: The Journal of biological chemistry, Vol. 273, Issue 52, pp. 34671-4, (1999) (PubMed).

Details zu STRAP

Target: STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))

Andere Bezeichnung: STRAP (STRAP Produkte)

Synonyme: MAWD antikoerper, PT-WD antikoerper, UNRIP antikoerper, zgc:56677 antikoerper, zgc:77604 antikoerper, mawd antikoerper, pt-wd antikoerper, unrip antikoerper, AW557906 antikoerper, C78091 antikoerper, C79202 antikoerper, Unrip antikoerper, serine/threonine kinase receptor associated protein antikoerper, tetratricopeptide repeat domain 5 antikoerper, serine/threonine kinase receptor associated protein L homeolog antikoerper, serine/threonine kinase receptor associated protein S homeolog antikoerper, STRAP antikoerper, TTC5 antikoerper, strap antikoerper, strap.L antikoerper, strap.S antikoerper, Strap antikoerper

Hintergrund: The transforming growth factor beta (TGF-beta) family of cytokines plays diverse and important roles in growth, development, and differentiation. Three high affinity TGF-beta receptor types have been characterized. Both type I and type II receptors are type I transmembrane proteins which contain a Ser/Thr-kinase in their cytosolic domains. Type III receptor, also known as betaglycan, has no cytosolic signaling motif and functions in the presentation of TGF-beta to the type I and type II receptors. The cytosolic domain kinase of the type I receptor is thought to be transphosphorylated by the corresponding kinase of the type II receptor, leading to activation of downstream substrates. Ser/Thr receptor associated protein (STRAP) contains six WD domains, which are characteristic of signal transduction proteins. STRAP can associate with both TGF-betaI and TGF-betaII receptors and overexpression of STRAP leads to inhibition of TGF-beta-dependent transcriptional activation. STRAP is expressed ubiquitously in species ranging from yeast to human. Thus, STRAP may be an important element of TGF-beta signal transduction pathways in a variety of tissues and species.

Molekulargewicht: 39 kDa