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ube3a Antikörper (AA 501-712)

ube3a Reaktivität: Human, Maus WB, IF Wirt: Maus Monoclonal 13-UBE3A unconjugated
Produktnummer ABIN968525
  • Target Alle ube3a Antikörper anzeigen
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    Bindungsspezifität
    • 15
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-712
    Reaktivität
    • 51
    • 11
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 47
    • 4
    Maus
    Klonalität
    • 47
    • 4
    Monoklonal
    Konjugat
    • 28
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ube3a Antikörper ist unkonjugiert
    Applikation
    • 27
    • 17
    • 16
    • 13
    • 13
    • 9
    • 8
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Human
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse UBE3A aa. 501-712
    Klon
    13-UBE3A
    Isotyp
    IgG1
    Top Product
    Discover our top product ube3a Primärantikörper
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    Related Products: ABIN968584, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Nawaz, Lonard, Smith, Lev-Lehman, Tsai, Tsai, OMalley: "The Angelman syndrome-associated protein, E6-AP, is a coactivator for the nuclear hormone receptor superfamily." in: Molecular and cellular biology, Vol. 19, Issue 2, pp. 1182-9, (1999) (PubMed).

    Matsuura, Sutcliffe, Fang, Galjaard, Jiang, Benton, Rommens, Beaudet: "De novo truncating mutations in E6-AP ubiquitin-protein ligase gene (UBE3A) in Angelman syndrome." in: Nature genetics, Vol. 15, Issue 1, pp. 74-7, (1997) (PubMed).

  • Target
    ube3a (Ubiquitin Protein Ligase E3A (ube3a))
    Andere Bezeichnung
    UBE3A (ube3a Produkte)
    Synonyme
    ANCR antikoerper, AS antikoerper, E6-AP antikoerper, EPVE6AP antikoerper, HPVE6A antikoerper, DDBDRAFT_0188760 antikoerper, DDBDRAFT_0302447 antikoerper, DDB_0188760 antikoerper, DDB_0302447 antikoerper, ube3a antikoerper, im:7140733 antikoerper, zgc:92173 antikoerper, 4732496B02 antikoerper, 5830462N02Rik antikoerper, A130086L21Rik antikoerper, Hpve6a antikoerper, mKIAA4216 antikoerper, As antikoerper, CG6190 antikoerper, Dmel\\CG6190 antikoerper, Dube3a antikoerper, UBE3A antikoerper, dUBE3A antikoerper, das antikoerper, dube3A antikoerper, dube3a antikoerper, MGC69536 antikoerper, UME3A antikoerper, ubiquitin protein ligase E3A antikoerper, ubiquitin-protein ligase E3A antikoerper, Ubiquitin protein ligase E3A antikoerper, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) S homeolog antikoerper, ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) antikoerper, UBE3A antikoerper, ube3a antikoerper, LOC100194730 antikoerper, Ube3a antikoerper, ube3a.S antikoerper, Eint_040430 antikoerper
    Hintergrund
    Protein ubiquitination is the end product of a multienzyme cascade that involves sequential thiol-ester bond interactions between ubiquitin and enzymes termed E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin protein ligases. UBE3A (human papilloma virus E6-associated protein, E6-AP) is an E3 ubiquitin protein ligase that is linked to the neurological disorder Angelman syndrome. It mediates the interaction of human papilloma virus types 16 and 18 E6 proteins with p53, which targets p53 to the ubiquitination-proteasome degradation pathway. The C-terminal region of UBE3A contains a hect domain, which is found in many E3 ubiquitin protein ligases, while the central region contains an E6 binding region. UBE3A is expressed in the cytoplasm and nucleus of many tissues. The interaction of UBE3A with the progesterone receptor coactivates transciptional activity of the receptor in the presence of bound hormone. Thus, UBE3A is an essential component of the ubiquitination degradation pathway and the nuclear hormone receptor signal transduction pathways. This antibody is routinely tested by western blot analysis.
    Synonyms: Ubiquitin Protein Ligase 3A
    Molekulargewicht
    100 kDa
    Pathways
    Intracellular Steroid Hormone Receptor Signaling Pathway
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